Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome

BMC Cardiovascular Disorders

Research Article

Peizhen Gao¹  Pingping Yan²  Jinjin Zhang²  Xianhao Wu³ 

[1] Department of Beixinjing Community Health Center, 200335, Shanghai, People’s Republic of China;Department of Cardiology, North Huashan Hospital of Fudan University, 201907, Shanghai, People’s Republic of China;Department of Cardiology, Tongren Hospital, 200050, Shanghai, People’s Republic of China;

关键词: Acute coronary syndrome;    Serum cystatin C;    Glomerular filtration rate;    Correlation study;   

DOI  :  10.1186/s12872-017-0483-8

 received in 2016-07-10, accepted in 2017-01-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to evaluate the predictive value of cystatin C (CysC) and estimated glomerular filtration rate (eGFR) regarding vascular lesions and their severity in patients with acute coronary syndrome (ACS).MethodsAccording to the results of coronary angiography, 195 ACS patients were divided into a single-vascular-lesion group (91 cases), a dual-vascular-lesion group (67 cases), and a multiple-vascular-lesion group (37 cases) to assess the severity of coronary artery disease according to Gensini scores and to analyze the correlations of CysC and eGFR level with vascular lesions and severity in ACS patients.ResultsIntergroup comparisons of univariate and multivariate regression analyses showed that CysC was positively correlated with vascular lesions (P < 0.05), but eGFR showed no correlation. Regarding the severity of vascular lesions, CysC was positively correlated with Gensini score (Pearson’s correlation coefficient r = 0.1811, P < 0.05), but eGFR was not correlated (P > 0.05).ConclusionsSerum CysC levels could reflect the severity of vascular lesions in ACS patients, and a high CysC level had predictive value regarding the severity of vascular lesions in ACS.

【 授权许可】

CC BY   
© The Author(s). 2017