Study protocol: the Whitehall II imaging sub-study

BMC Psychiatry

Study Protocol

Steen Moeller¹  Edward Auerbach¹  Essa Yacoub¹  Kâmil Uğurbil¹  Junqian Xu²  Aaron T Hess³  Eric J Brunner⁴  Martin J Shipley⁴  Mika Kivimäki⁴  Archana Singh-Manoux⁵  Enikő Zsoldos⁶  Abda Mahmood⁶  Charlotte L Allan⁶  Clare E Mackay⁶  John R Geddes⁶  Vyara Valkanova⁶  Klaus P Ebmeier⁶  Rita Haapakoski⁶  Claire E Sexton⁶  Anya Topiwala⁶  Nicola Filippini⁷  Natalie L Voets⁸  Stephen M Smith⁸  Janine Bijsterbosch⁸  Karla L Miller⁸  Stamatios N Sotiropoulos⁸  Stuart Clare⁸  Mark Jenkinson⁸  Ludovica Griffanti⁸  Jesper Andersson⁸  Gholamreza Salimi-Khorshidi⁸ 

[1] Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA;Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA;Icahn School of Medicine at Mount Sinai, New York, NY, USA;Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, UK;Department of Epidemiology & Public Health, University College London, London, UK;Department of Epidemiology & Public Health, University College London, London, UK;Centre for Research in Epidemiology and Population Health, Hôpital Paul Brousse, INSERM, U1018, 94807, Villejuif, Cedex, France;Department of Psychiatry, University of Oxford, Warneford Hospital, OX3 7JX, Oxford, UK;Department of Psychiatry, University of Oxford, Warneford Hospital, OX3 7JX, Oxford, UK;Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK;Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK;

关键词: Epidemiology;    Magnetic resonance imaging;    Diffusion tensor imaging;    White matter;    Functional MRI;    Connectome;    Resting state brain networks;    Neuropsychology;    Dementia;    Affective disorders;   

DOI  :  10.1186/1471-244X-14-159

 received in 2014-05-16, accepted in 2014-05-21,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study.Methods/designA total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012–2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60–85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study.DiscussionThe integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

【 授权许可】

Unknown   
© Filippini et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.