Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia

BMC Musculoskeletal Disorders

Research Article

Olivia Arodell¹  Jan L. Bjersing²  Anette Larsson³  Åsa Cider³  Kaisa Mannerkorpi⁴  Kerstin Landin-Wilhelmsen⁵ 

[1] Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 480, Guldhedsgatan 10, 40530, Göteborg, Sweden;Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 480, Guldhedsgatan 10, 40530, Göteborg, Sweden;Sahlgrenska University Hospital, Rheumatology, Göteborg, Sweden;Institute of Neuroscience and Physiology, Section of Health and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Institute of Neuroscience and Physiology, Section of Health and Rehabilitation, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;Sahlgrenska University Hospital, Physiotherapy and Occupational therapy, Göteborg, Sweden;Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 480, Guldhedsgatan 10, 40530, Göteborg, Sweden;Section of Endocrinology, Sahlgrenska Academy, Sahlgrenska University Hospital, Institution of Medicine, University of Gothenburg, Gothenburg, Sweden;

关键词: Exercise;    IGF;    Fibromyalgia;    Fatigue;    Pain;   

DOI  :  10.1186/s12891-017-1402-y

 received in 2016-06-28, accepted in 2017-01-14,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIncreased Serum insulin-like growth factor-1 (S-IGF-1) has been noted after physical activity in healthy subjects, while the acute release of S-IGF-1 in relation to exercise has not previously been studied in women with fibromyalgia (FM). S-IGF-1 and its binding protein (S-IGFBP-3) are mediated by growth hormone and have anabolic effects on the skeletal muscle. Aim of the study was to investigate acute release of IGF-1 after aerobic exercise in women with FM.MethodsThe acute effect of physical exercise on S-IGF-1 and S-IGFBP-3 were studied in 22 women with FM and in 27 healthy controls during moderate and high-intensity cycling (i.e. ratings 12–13 and 15–17, on Borg’s perceived exertion scale (RPE), respectively). Self-reported pain and fatigue were recorded. Differences within and between the two groups were analyzed.ResultsAfter 15 min of bicycling, S-IGF-1 and S-IGFBP-3 increased both within the group with FM and in the healthy controls (p < 0.01). The increases in S-IGF-1 did not significantly differ between the women with FM and the healthy control group (mean increase 11 ± 10 vs. 11 ± 15 ng/ml and 13 ± 10 vs. 19 ± 22 ng/ml) when bicycling at moderate or high intensity, respectively. Self-reported pain and fatigue during exercise, irrespective of intensity, were higher in women with FM compared with healthy controls (p < 0.001).ConclusionsFifteen minutes bicycling at moderate intensity was sufficient to acutely mobilise S-IGF-1 in women with FM similarly to healthy controls in spite of higher score of fatigue and pain in women with FM. Hence, patients with FM were able to activate their skeletal muscle metabolism during a short, moderate bout of exercise and were not resistant to training effects. The result is important for encouraging clinical rehabilitation of patients with FM who commonly exercise at a moderate, rather than at a high-intensity level.Trial registrationClinicalTrials.govNCT01592916, May 4, 2012.

【 授权许可】

CC BY   
© The Author(s). 2017