Evaluation of the diagnostic accuracy of nonstructural protein 1 Ag-based tests for dengue virus in Asian population: a meta-analysis

BMC Infectious Diseases

Research Article

Honghe Zhang¹  Yihua Wu²  Jun Yang²  Yaping Zheng³  Qing Yuan³  Xiaoyun Shan³  Xiangmei Wang³ 

[1] Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing ChunRoad, 310003,, Hangzhou, Zhejiang, China;Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing ChunRoad, 310003,, Hangzhou, Zhejiang, China;Department of Public Health, Hangzhou Normal University School of Medicine, 16 Xuelin Street, 310016, Hangzhou, Zhejiang, China;Department of Clinical Laboratory, Jin Hua Hospital, Zhejiang University, 351 Ming Yue Street, 321000,, Jin Hua, Zhejiang, China;

关键词: Dengue Virus;    Area Under Curve;    Dengue Fever;    Dengue Hemorrhagic Fever;    Diagnostic Odds Ratio;   

DOI  :  10.1186/s12879-015-1088-4

 received in 2015-01-29, accepted in 2015-08-04,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundNonstructural protein 1 (NS1) Ag-based tests are useful for detecting dengue virus (DENV), but there is lack of evidence on the diagnostic accuracy of NS1 Ag-based tests in Asian population. Thus, we conducted this meta-analysis to obtain the overall estimated and summarized performance of the NS1 Ag-based tests in the detection of DENV in Asia.MethodsPubMed, Embase and Medline were searched for studies that evaluated the diagnostic validity of NS1 Ag-based tests between January 1990 and November 2014. Data were analyzed by Meta-Disc and STATA software.ResultsA total of 18 studies including 3342 dengue cases and 1904 control cases which fulfilled the inclusion criteria were considered for analysis. The pooled sensitivity and specificity for NS1 Ag-based tests was 66 % (95 % CI 64.5–67.5) and 97.9 % (95 % CI 97.3–100), respectively. STRIP has the overall highest sensitivity (72.9 %, 95 % CI 70.1–75.5). According to viral serotype, the test with the highest sensitivity for DENV1, DENV2 and DENV3 were Platelia (83.7 %, 95 % CI 79.7–87.1), Panbio (71.8 %, 95 % CI 65.5–80.9) and STRIP (81.9 %, 95 % CI 75.5–87.2) respectively. The highest sensitivity for primary infection was Platelia (95.1 %, 95 % CI 92.6–96.9) and for secondary infection was STRIP (64 %, 95 % CI 53.2–73.9).ConclusionOur meta-analysis suggests that NS1 Ag-based test is a good diagnostic method for DENV with a high specificity. However, viral serotype, serological status, clinical severity and the duration of illness are the main factors influencing the diagnostic accuracy.

【 授权许可】

CC BY   
© Shan et al. 2015