Prophylactic antibiotic regimens in tumor surgery (PARITY) survey

BMC Musculoskeletal Disorders

Research Article

Ginger Holt¹  Herbert Schwartz¹  Jay Wunder²  Peter Ferguson²  Mohit Bhandari³  Antonella Racano³  Khaled Hasan³  Brad Petrisor³  Michelle Ghert³  Benjamin Deheshi³  Forough Farrokhyar⁴ 

[1] Department of Orthopedic Surgery, Vanderbilt University, Nashville, TN, USA;Department of Surgery Surgery, University of Toronto, Toronto, ON, Canada;Department of Surgery, McMaster University, Hamilton, ON, Canada;Department of Surgery, McMaster University, Hamilton, ON, Canada;Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada;

关键词: Antibiotic Regimen;    Suction Drain;    Large Randomized Control Trial;    Musculoskeletal Tumor;    Orthopaedic Oncology;   

DOI  :  10.1186/1471-2474-13-91

 received in 2011-07-15, accepted in 2012-06-07,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundDeep infection following endoprosthetic limb reconstruction for sarcoma of the long bones is a devastating complication occurring in 15% of sarcoma patients. Optimizing infection protocols and conducting definitive surgical trials are critical to improving outcomes. In this study, the PARITY (P rophylactic A ntibiotic R egimens i n T umor Surgery) investigators aimed to examine surgeon preferences in antibiotic prophylaxis and perceptions about current evidence, as well as to ascertain interest in resolving uncertainty in the evidence with clinical trials.MethodsWe used a cross-sectional survey to examine current practice in the prescription of prophylactic antibiotics in Musculoskeletal Tumor Surgery. The survey was approved by our institution’s Ethics Board and emailed to all Active Members of the Musculoskeletal Tumor Society (MSTS) and Canadian Orthopaedic Oncology Society (CANOOS). Survey answers were collected using an anonymous online survey tool.ResultsOf the 96 surgeons who received the questionnaire, 72 responded (75% response rate (% CI: 65.5, 82.5%)). While almost all respondents agreed antibiotic regimens were important in reducing the risk of infection, respondents varied considerably in their choices of antibiotic regimens and dosages. Although 73% (95% CI: 61, 82%) of respondents prescribe a first generation cephalosporin, 25% favor additional coverage with an aminoglycoside and/or Vancomycin. Of those who prescribe a cephalosporin, 33% prescribe a dosage of one gram for all patients and the reminder prescribe up to 2 grams based on body weight. One in three surgeons (95% CI: 25, 48%) believes antibiotics could be discontinued after 24 hours but 40% (95% CI: 30, 53%) continue antibiotics until the suction drain is removed. Given the ongoing uncertainty in evidence to guide best practices, 90% (95% CI: 81, 95%) of respondents agreed that they would change their practice if a large randomized controlled trial showed clear benefit of an antibiotic drug regimen different from what they are currently using. Further support for a clinical trial was observed by an overwhelming surgeon interest (87%; 95% CI: 77, 93%) in participating in a multi-center randomized controlled study.ConclusionThe current lack of guidelines for the prescription of prophylactic antibiotics in Musculoskeletal Tumor Surgery has left Orthopaedic Oncologists with varying opinions and practices. The lack of current evidence and strong surgeon support for participating in a definitive study provides strong rationale for clinical trials.

【 授权许可】

CC BY   
© 2012 Hasan et al.; licensee BioMed Central Ltd. 2012