The contemporary role of Impella in a comprehensive mechanical circulatory support program: a single institutional experience

BMC Cardiovascular Disorders

Research Article

Dario Winterton¹  Marina Pieri¹  Alberto Zangrillo¹  Federico Pappalardo¹  Michele De Bonis²  Rachele Contri³  Matteo Montorfano³  Antonio Colombo³ 

[1] Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy;Department of Cardiac Surgery, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy;Department of Interventional Cardiology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy;

关键词: Mechanical circulatory support;    Cardiogenic shock;    IMPELLA;    ECMO;   

DOI  :  10.1186/s12872-015-0119-9

 received in 2014-10-06, accepted in 2015-09-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundThe treatment of cardiogenic shock with percutaneous mechanical circulatory support (MCS) is attractive: however, at present it is not clear which is the best strategy, as no survival benefit has been demonstrated for any device as single therapy. Aim of this study is to describe the role of percutaneous Impella in a comprehensive MCS program.MethodsObservational study on 22 patients supported with the Impella device in our hospital from May 2013 to June 2014.ResultsFour patients (18 %) were treated with Impella alone, 8 patients (36 %) were treated with Impella and IABP, 6 patients (27 %) with Impella and VA ECMO, and 4 patients (18 %) with Impella, IABP and VA ECMO.The cause of cardiogenic shock was myocardial infarction (CSMI) in 9 patients (41 %), postcardiotomic cardiogenic shock in 5 (23 %), and a miscellaneous of other causes in the remaining 8 (36 %). Eight Impella devices (36 %) were placed under transesophageal echocardiographic guidance, while 14 (64 %) under fluoroscopy. The device was removed with manual compression at bedside and no vascular complications were observed.Duration of Impella support was 107 (54–141) hours and duration of ventilation was 48 (14–92) hours. Hemolysis occurred in 6 patients (27 %), while major bleeding in 4 patients (18 %). Survival was 73 %: 13 patients (58 %) showed recovery of cardiac function; 1 patient (5 %) was bridged to left ventricular assist device (LVAD) implantation, 1 patient (5 %) to heart transplantation (HTx) and 1 patient (5 %) received a BiVAD and was eventually bridged to HTx.ConclusionsOur data suggest that a multi-device approach, encompassing active LV support with Impella, is safe and can significantly improve survival in patients with cardiogenic shock.

【 授权许可】

CC BY   
© Pieri et al. 2015