Low birth weight contributed to increased serum IL-6 levels in infantile respiratory syncytial virus infection

BMC Pediatrics

Research Article

Shan-Shan Xu¹  Xue-Jing Li²  Jin-Ling Liu²  Xi-Ling Wu²  Yuan-Jian Sheng²  Xue-Feng Xu² 

[1] Department of Neonatology, The Children’s Hospital, Zhejiang University School of Medicine, 310052, Hangzhou, People’s Republic of China;Department of Respiratory Medicine, The Children’s Hospital, Zhejiang University School of Medicine, 310052, Hangzhou, China;

关键词: Cytokine;    Infant;    Lower respiratory tract infection;    Low birth weight;    Respiratory syncytial virus;   

DOI  :  10.1186/s12887-017-0961-2

 received in 2016-06-10, accepted in 2017-12-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo evaluate the role of serum cytokines in the pathogenesis of respiratory syncytial virus (RSV) infection in infants with low birth weight (LBW).MethodsA prospective observational study was performed, and hospitalized children with lower respiratory tract infection (LRTI) were recruited. Three hundred fifty-eight patients < 1 year met the inclusion criteria: 116 patients had only RSV infection (RSV group); 242 patients had no RSV or other specific pathogen (non-RSV group). Serum interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were detected through flow cytometry.ResultsNo significant differences in serum IL-2, 4, 6, 10, and IFN-γ levels were observed between the RSV and non-RSV groups. For RSV infected infants with or without wheezing, delivery mode had no obvious effect on the changes of serum cytokine levels. However, the level of IL-6 in the RSV-infected infants with LBW was significantly higher than that in infants with normal birth weight.ConclusionsSerum IL-6 level was significantly increased in RSV infected infants with LBW. It is likely that the specific serum cytokine pattern will contribute to our understanding of the pathogenesis of RSV infections, especially in RSV-infected infants with LBW.

【 授权许可】

CC BY   
© The Author(s). 2017