Pharmacokinetics of ranitidine in preterm and term neonates with gastroesophageal reflux

BMC Pediatrics

Research Article

Ismael Lares Asseff¹  Jose Antonio Godinez Nájera¹  Fausto Zamura Torres¹  Hugo Juárez Olguín²  Alejandra Toledo López²  Gabriela Pérez Guillé²  Graciela Benitez Gaucin³ 

[1] Interdisciplinary Centre of Investigation for Integral and Regional Development, Durango Unit, National Polytechnic Institute, Durango, Mexico;Laboratory of Pharmacology, National Institute of Pediatrics, and Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Av Imán #1, 3er piso, Col Cuicuilco, CP 04530, Mexico City, Mexico;Pediatrics and Neonatology Services, General Hospital of Durango, Durango, Mexico;

关键词: Gestational age;    Full-term;    Neonates;    Pre-term;    Ranitidine;    Pharmacokinetics;   

DOI  :  10.1186/s12887-016-0630-x

 received in 2016-04-26, accepted in 2016-07-08,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe aim of this study was to determine the effect of gestational age on pharmacokinetics of ranitidine in newborns with gastroesophageal reflux.MethodsA prospective, descriptive and pharmacokinetic study was carried out in 30 pre-term and 20 full-term babies. 3 mg/kg of ranitidine was administered intravenously to all the babies and at 0.25, 0.5, 1, 2, 4, and 8 h following the administration, samples of blood were drawn to assess ranitidine levels using high performance liquid chromatographic technique.ResultsPharmacokinetics of ranitidine had a bi-exponential behavior with a half-life elimination of (t1/2el) 2.79 h, area under curve (AUC) of 1688 ng/mL, volume of distribution (Vd) of 1.44 L/kg, and clearance (Cl) of 5.9 L/kg/h. The median plasmatic concentration in pre-terms was 1113 ng/mL and 280 ng/mL in full-terms. Vd, t1/2 and Cl presented high values in preterm although the correlation of Cl with glomerular filtration in term newborns was better.ConclusionsPlasma levels of ranitidine depend on the gestational age of the newborns. However, the possible relationship between after-birth age and pharmacokinetics of the neonates as their internal organs get matured without minding their gestational background.

【 授权许可】

CC BY   
© The Author(s). 2016