Etiology and prognosis of acute viral encephalitis and meningitis in Chinese children: a multicentre prospective study

BMC Infectious Diseases

Research Article

Junhong Ai¹  Gang Liu¹  Zhengde Xie¹  Guo Zheng²  Jing Chen²  Kunling Shen³  Zongbo Chen⁴  Yuning Li⁵  Yong Yang⁶ 

[1] Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Virology Laboratory, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, 100045, Beijing, China;Nanjing Children’s Hospital, Jiangsu province, Nanjing, China;National Clinical Research Center for Respiratory Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Respiratory Department, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, 100045, Beijing, China;The Affiliated Hospital of Qingdao University, Shandong province, Qingdao, China;The First Hospital of Lanzhou University, Gansu province, Lanzhou, China;The First Hospital of Yulin, Shanxi province, Yulin, China;

关键词: Viral encephalitis;    Viral meningitis;    Etiology;    Prognosis;    Children;   

DOI  :  10.1186/s12879-017-2572-9

 received in 2016-07-12, accepted in 2017-06-27,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundIn China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children.MethodsThis was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5.88 ± 3.60 years and 6.39 ± 3.57 years, respectively. Real-time reverse transcription PCR and multiplex PCR were used to detect human enteroviruses and herpes viruses in cerebrospinal fluid (CSF) of patients with encephalitis or meningitis. The enzyme-linked immune absorbent assay (ELISA) was used for detecting IgM antibody against Japanese encephalitis virus (JEV) in CSF and against mumps virus, tick-borne encephalitis virus (TBEV), dengue virus and rubella virus in acute serum. The clinical and outcome data were collected during patients’ hospitalization.ResultsThe etiology of viral encephalitis was confirmed in 52.5% patients. The primary pathogen was human enteroviruses (27.7%) in viral encephalitis. The incidence of sequelae and the fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The etiology of viral meningitis was identified in 42.8% cases. The leading pathogen was also human enteroviruses (37.7%) in viral meningitis. The prognosis of viral meningitis was favorable with only 0.7% patients had neurological sequelae.ConclusionsHuman enteroviruses were the leading cause both in acute viral encephalitis and viral meningitis in children. The incidence of sequelae and fatality rate of viral encephalitis with confirmed etiology were 7.5% and 0.8%, respectively. The prognosis of viral meningitis was favorable compared to viral encephalitis.

【 授权许可】

CC BY   
© The Author(s). 2017