Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population

BMC Cancer

Research Article

Côme Lepage¹  Vanessa Cottet¹  Anne-Marie Bouvier¹  Jean Faivre¹  Marion Chauvenet¹  Valérie Jooste¹ 

[1] Registre Bourguignon des Cancers Digestifs; Inserm U866, Université de Bourgogne; CHU Dijon, BP 87900 21079, F-21079, Dijon Cedex, France;

关键词: Rectal Cancer;    Birth Cohort;    Time Trend;    Cumulative Risk;    Colorectal Cancer Incidence;   

DOI  :  10.1186/1471-2407-11-282

 received in 2010-03-24, accepted in 2011-06-30,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundFrance stands among high-risk areas for colorectal cancer. Different trends in CRC incidence are reported around the world. The aim of this study was to provide temporal trends in CRC incidence over a 30-year period in a French well-defined population.MethodsBetween 1976 and 2005, 17,028 new cases were registered by the Burgundy digestive cancer registry. The mean variations in age-standardized incidence rates were estimated using a Poisson regression adjusted for age for each gender and location. The cumulative risk by birth cohort of developing a cancer over the age range 0-74 years was estimated using an age-cohort model.ResultsIncidence rates for right and left colon cancers increased more rapidly in males (respectively +11.7% and +10.3% on average by 5-year period) than in females (respectively +5.9% and +6.1%). It remained stable for sigmoid cancers in males (-0.1%) and decreased in females (-5.2%). It also decreased for rectal cancers both in males (-2.7%) and in females (-2.0%). The cumulative risk increased from 3.9% for males born around 1900 to 4.9% for those born around 1930 and then slightly decreased (4.5% among those born around 1950). It remained at the same level for females born around 1900 (2.7%) as for those born around 1930 (2.7%) and then slightly increased (2.9%) for those born around 1950. For right colon cancers, the cumulative risk increased strikingly in successive birth cohorts from 0.53% to 1.2% in males and 0.55% to 0.77% in females. The corresponding cumulative risks for the left colon were 0.24% and 0.42% in males and 0.14% and 0.29% in females. For sigmoid cancer, they decreased from 1.59% to 1.08% in males, and 0.88% to 0.80% in females.ConclusionTemporal variations in incidence rates of colorectal cancers differed according to subsite, suggesting different aetiological factors and implications for diagnosis and screening strategies. Total colonoscopy must be the preferred strategy in high-risk groups or after a positive faecal occult blood test.

【 授权许可】

Unknown   
© Chauvenet et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.