African-American inflammatory bowel disease in a Southern U.S. health center

BMC Gastroenterology

Research Article

Hemanth Veluswamy¹  Walter Cromer²  Michael J Mathis²  Ganta V Chaitanya³  Mihir Patel³  Shannon Wells³  Jonathan S Alexander³  Moheb Boktor⁴  Balaji Datti⁴  Paul A Jordan⁴  Kunal Suryawala⁴  Ellenmarie Zwank⁴  Kenneth Manas⁴  Kondal Baig⁴  Ankur Sheth⁴  Erik Salvatierra⁴  Annette Painter⁵  Alireza Minagar⁶ 

[1] Dept. of Molecular & Cellular Physiology, 1501 Kings Highway, 71130-3932, Shreveport, LA, USA;LSUHSC-S Cell Biology & Anatomy, 1501 Kings Highway, 71130-3932, Shreveport, LA, USA;LSUHSC-S Dept. of Molecular & Cellular Physiology, 1501 Kings Highway, 71130-3932, Shreveport, LA, USA;LSUHSC-S Gastroenterology & Hepatology, 1501 Kings Highway, 71130-3932, Shreveport, LA, USA;LSUHSC-S Information Services, 1501 Kings Highway, 71130-3932, Shreveport, LA, USA;LSUHSC-S Neurology, 1501 Kings Highway, 71130-3932, Shreveport, LA, USA;

关键词: Inflammatory Bowel Disease;    Ulcerative Colitis;    Ulcerative Colitis Patient;    African American;    African American Male;   

DOI  :  10.1186/1471-230X-10-104

 received in 2010-02-01, accepted in 2010-09-09,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundInflammatory Bowel Diseases (IBD) remain significant health problems in the US and worldwide. IBD is most often associated with eastern European ancestry, and is less frequently reported in other populations of African origin e.g. African Americans ('AAs'). Whether AAs represent an important population with IBD in the US remains unclear since few studies have investigated IBD in communities with a majority representation of AA patients. The Louisiana State University Health Sciences Center in Shreveport (LSUHSC-S) is a tertiary care medical center, with a patient base composed of 58% AA and 39% Caucasian (W), ideal for evaluating racial (AA vs. W) as well and gender (M vs. F) influences on IBD.MethodsIn this retrospective study, we evaluated 951 visits to LSUHSC-S for IBD (between 2000 to 2008) using non-identified patient information based on ICD-9 medical record coding (Crohn's disease 'CD'-555.0- 555.9 and ulcerative colitis 'UC'-556.0-556.9).ResultsOverall, there were more cases of CD seen than UC. UC and CD affected similar ratios of AA and Caucasian males (M) and females (F) with a rank order of WF > WM > AAF > AAM. Interestingly, in CD, we found that annual visits per person was the highest in AA M (10.7 ± 1.7); significantly higher (* -p < 0.05) than in WM (6.3 ± 1.0). Further, in CD, the female to male (F: M) ratio in AA was significantly higher (*- p < 0.05) (1.9 ± 0.2) than in Caucasians (F:M = 1.3 ± 0.1) suggesting a female dominance in AACD; no differences were seen in UC F: M ratios.ConclusionAlthough Caucasians still represent the greatest fraction of IBD (~64%), AAs with IBD made up >1/3 (36.4%) of annual IBD cases from 2000-2008 at LSUHSC-S. Further studies on genetic and environments risks for IBD risk in AAs are needed to understand differences in presentation and progression in AAs and other 'non-traditional' populations.

【 授权许可】

Unknown   
© Veluswamy et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.