A retrospective analysis of Victorian and South Australian clinical registries for prostate cancer: trends in clinical presentation and management of the disease

BMC Cancer

Research Article

David Roder¹  Kerri Beckmann¹  Kim Moretti²  Rasa Ruseckaite³  Sue Evans³  Jeremy Millar⁴  Michael O’Callaghan⁵ 

[1] Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia;Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia;South Australian Prostate Cancer Clinical Outcomes Collaborative, Department of Urology, Repatriation General Hospital, Adelaide, SA, Australia;Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA, Australia;Freemasons Foundation Centre for Men’s Health and Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia;Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia;Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia;Radiation Oncology, Alfred Health, Melbourne, VIC, Australia;South Australian Prostate Cancer Clinical Outcomes Collaborative, Department of Urology, Repatriation General Hospital, Adelaide, SA, Australia;Flinders Centre for Innovation in Cancer, Flinders University, Adelaide, SA, Australia;Freemasons Foundation Centre for Men’s Health and Discipline of Medicine, University of Adelaide, Adelaide, SA, Australia;

关键词: Prostate cancer;    Clinical registry;    Trends;    Treatments;   

DOI  :  10.1186/s12885-016-2655-9

 received in 2015-12-14, accepted in 2016-07-30,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundProstate cancer (PCa) is the most commonly diagnosed malignancy reported to Australian cancer registries with numerous studies from individual registries summarizing diagnostic and treatment characteristics. The aim of this study was to describe annual trends in clinical and treatment characteristics, and changes in surveillance practice within a large combined cohort of men with PCa in South Australia (SA) and Victoria, Australia in 2008–2013.MethodsCommon data items from clinical registries in SA and Victoria were merged to develop a cross-jurisdictional dataset consisting of 13,598 men with PCa. Frequencies were used to describe these variables using the National Comprehensive Cancer Network risk of disease progression categories in 10 year age groups. A logistic regression analysis was performed to assess the impact of a number of factors (both individually and together) on the likelihood of men receiving no active treatment within twelve months of the diagnosis (i.e. managed with active surveillance/watchful waiting).ResultsTrend analysis showed that over time: (1) men in SA and Victoria are being diagnosed at older age in 2013, 66.1 (SD = 9.7) years compared to 2009 (64.5 (SD = 9.7)); (2) diagnostic methods and characteristics have changed with time; and (3) types of the treatments have changed, with more men having no active treatment. The majority of men were diagnosed with Prostate-Specific Antigen (PSA) <10 ng/mL (66 %) and Grade Group < 4 (65 %). Nearly seventy percent received radical treatment within 12 months of diagnosis, while ~20 % had no active treatment. In 14 % of cases treatment was not recorded or had not commenced. Having no active treatment was strongly associated older age, lower PSA and lower Grade Group at diagnosis, and in 2013 it was offered more frequently (more than 3 times) than in 2009 (OR = 2.63, 95 % CI: 2.16–3.22).ConclusionsFindings of this study provide the first cross-jurisdictional description of PCa characteristics and management in Australia. These findings will provide benchmarking for ongoing monitoring and feedback of disease management and outcomes of PCa through the Prostate Cancer Outcomes Registry–Australia New Zealand to improve evidence-based practice.

【 授权许可】

CC BY   
© The Author(s). 2016