Classical risk factors of cardiovascular disease among Chinese male steel workers: a prospective cohort study for 20 years

BMC Public Health

Research Article

Jianfeng Huang¹  Dongfeng Gu²  Jichun Chen²  Dongling Sun²  Shufeng Chen²  Xiufang Duan²  Jingfeng Ji²  Xigui Wu²  Jianxin Li²  Enchun Pan²  Jie Cao²  Xiangfeng Lu² 

[1] Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Department of Evidence Based Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;

关键词: Mean Arterial Pressure;    Total Cholesterol;    Framingham Heart Study;    Coronary Heart Disease Event;    Classical Risk Factor;   

DOI  :  10.1186/1471-2458-11-497

 received in 2011-02-18, accepted in 2011-06-25,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundCardiovascular disease (CVD) constitutes a major public health problem in China and worldwide. We aimed to examine classical risk factors and their magnitudes for CVD in a Chinese cohort with over 20 years follow-up.MethodsA cohort of 5092 male steelworkers recruited from 1974 to 1980 in Beijing of China was followed up for an average of 20.84 years. Cox proportional-hazards regression model were used to evaluate the risk of developing a first CVD event in the study participants who were free of CVD at the baseline.ResultsThe multivariable-adjusted hazard ratio (HR) associated with every 20 mmHg rise in systolic blood pressure (SBP) was 1.63 in this Chinese male population, which was higher than in Caucasians. Compared to non-smokers, men who smoked not less than one-pack-a-day had a HR of 2.43 (95% confidence interval [CI], 1.75-3.38). The HR (95% CI) for every 20 mg/dl increase in total serum cholesterol (TC) and for every point rise in body mass index (BMI) was 1.13 (1.04-1.23) and 1.06 (1.02-1.09), respectively.ConclusionsOur study documents that hypertension, smoking, overweight and hypercholesterolemia are major conventional risk factors of CVD in Chinese male adults. Continued strengthening programs for prevention and intervention on these risk factors are needed to reduce the incidence of CVD in China.

【 授权许可】

Unknown   
© Ji et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.