The prognostic value of lactate dehydrogenase levels in colorectal cancer: a meta-analysis

BMC Cancer

Research Article

Yulong He¹  Zhao Wang¹  Jianbo Xu¹  Shirong Cai¹  Guanghua Li¹  Hui Wu¹ 

[1] Department of Gastrointestinal Surgery, First Affiliated Hospital of Sun Yat-sen University, 510080, Guangzhou, Guangdong Province, People’s Republic of China;

关键词: Lactate dehydrogenase;    Colorectal cancer;    Prognosis;    Meta-analysis;   

DOI  :  10.1186/s12885-016-2276-3

 received in 2015-03-22, accepted in 2016-03-13,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe prognostic value of lactate dehydrogenase levels in the prognosis of colorectal cancer patients has been assessed for years, although the results remain controversial and heterogeneous. Thus, we comprehensively reviewed the evidence from studies that evaluated lactate dehydrogenase levels in colorectal cancer patients to determine their effect.MethodsThe following databases were searched in September 2014 to identify studies that evaluated the prognostic value of lactate dehydrogenase levels in colorectal cancer: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials. We extracted hazard ratios (HRs) and the associated 95 % confidence intervals (CIs) from the identified studies, and performed random-effects model meta-analyses on the overall survival (OS) and progression-free survival (PFS). Thirty-two studies with a cumulative sample size of 8,261 patients were included in our analysis.ResultsOur meta-analyses revealed that high levels of lactate dehydrogenase were associated with poor OS (HR, 1.75; 95 % CI, 1.52–2.02) in colorectal cancer patients. However, this effect was not obvious in the OS of non-metastatic colorectal cancer patients (HR, 1.21; 95 % CI, 0.79–1.86). The prognostic value of lactate dehydrogenase levels on PFS was also not confirmed (HR, 1.36; 95 % CI, 0.98–1.87). Subgroup analyses revealed that the prognostic significance of lactate dehydrogenase was independent of study location, patient age, number of patients, metastasis, chemotherapy with anti-angiogenesis drugs, study type, or risk of bias.ConclusionsOur results indicate that high lactate dehydrogenase levels are associated with poor OS among colorectal cancer patients, although these levels are not significant predictors of PFS.

【 授权许可】

CC BY   
© Li et al. 2016