Contextualizing willingness to participate: recommendations for engagement, recruitment & enrolment of Kenyan MSM in future HIV prevention trials

BMC Public Health

Research Article

Shamshad Khan¹  Gloria Gakii²  Joshua Kimani³  Mary Gichuhi⁴  Elsabé du Plessis⁵  Robert R. Lorway⁵  Lisa Avery⁵  Ronnie P. Kaddu⁶  Sumit Dutta⁷  Monika Doshi⁸ 

[1] Department of Communication, University of Texas at San Antonio, One UTSA Circle, 78249, San Antonio, TX, USA;Department of Medical Microbiology, University of Nairobi, P.O. Box 30197–00100, Kenyatta National Hospital Campus, Nairobi, Kenya;Department of Medical Microbiology, University of Nairobi, P.O. Box 30197–00100, Kenyatta National Hospital Campus, Nairobi, Kenya;Department of Medical Microbiology, University of Manitoba, Room 543-745 Bannatyne Avenue, R3E0J9, Winnipeg, Canada;Partners for Health and Development in Africa, Geomaps Centre, 4th Floor Wing B, Matumbato Road, Upperhill, Nairobi, Kenya;The Centre for Global Public Health, University of Manitoba, Community Health Sciences, R070 Med Rehab Bldg, 771 McDermot Avenue, R3E0T6, Winnipeg, Canada;The Centre for Global Public Health, University of Manitoba, Community Health Sciences, R070 Med Rehab Bldg, 771 McDermot Avenue, R3E0T6, Winnipeg, Canada;Aga Khan Hospital, P.O. Box 83013–80100, Vanga Road, Mombasa, Kenya;The Centre for Global Public Health, University of Manitoba, Community Health Sciences, R070 Med Rehab Bldg, 771 McDermot Avenue, R3E0T6, Winnipeg, Canada;Dr. K.N. Modi University, INS-1, RIICO Industrial Area Ph-11, Newai, Dist. Tonk, 304021, Rajasthan, India;The Centre for Global Public Health, University of Manitoba, Community Health Sciences, R070 Med Rehab Bldg, 771 McDermot Avenue, R3E0T6, Winnipeg, Canada;Saath, 50 South Highland Street, 06119, West Hartford, CT, USA;

关键词: HIV vaccine;    Vaccine acceptability;    Willingness to participate;    Clinical trials;    Men who have sex with men (MSM);    Kenya;   

DOI  :  10.1186/s12889-017-4395-4

 received in 2016-08-23, accepted in 2017-05-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe HIV epidemic among men who have sex with men (MSM) continues to expand globally. The addition of an efficacious, prophylactic vaccine to combination prevention offers immense hope, particularly in low- and middle- income countries which bear the greatest global impact. However, in these settings, there is a paucity of vaccine preparedness studies that specifically pertain to MSM. Our study is the first vaccine preparedness study among MSM and female sex workers (FSWs) in Kenya. In this paper, we explore willingness of Kenyan MSM to participate in HIV vaccine efficacy trials. In addition to individual and socio-cultural motivators and barriers that influence willingness to participate (WTP), we explore the associations or linkages that participants draw between their experiences with or knowledge of medical research both generally and within the context of HIV/AIDS, their perceptions of a future HIV vaccine and their willingness to participate in HIV vaccine trials.MethodsUsing a social network-based approach, we employed snowball sampling to recruit MSM into the study from Kisumu, Mombasa, and Nairobi. A field team consisting of seven community researchers conducted in-depth interviews with a total of 70 study participants. A coding scheme for transcribed and translated data was developed and the data was then analysed thematically.ResultsMost participants felt that an HIV vaccine would bring a number of benefits to self, as well as to MSM communities, including quelling personal fears related to HIV acquisition and reducing/eliminating stigma and discrimination shouldered by their community. Willingness to participate in HIV vaccine efficacy trials was highly motivated by various forms of altruism. Specific researcher responsibilities centred on safe-guarding the rights and well-being of participants were also found to govern WTP, as were reflections on the acceptability of a future preventive HIV vaccine.ConclusionStrategies for engagement of communities and recruitment of trial volunteers for HIV vaccine efficacy trials should not only be grounded in and informed by investigations into individual and socio-cultural factors that impact WTP, but also by explorations of participants’ existing experiences with or knowledge of medical research as well as attitudes and acceptance towards a future HIV vaccine.

【 授权许可】

CC BY   
© The Author(s). 2017