Increased amygdala reactivity following early life stress: a potential resilience enhancer role

BMC Psychiatry

Research Article

Tomoya Matsumoto¹  Go Okada¹  Masahiro Takamura¹  Shigeru Toki¹  Yoshiyuki Takaishi¹  Shigeto Yamawaki¹  Yasumasa Okamoto¹  Tetsuya Yamamoto²  Greg J. Siegle³  Takashi Nakao⁴  Yumiko Kaseda⁵  Hiroyuki Muranaka⁶  Shinpei Yoshimura⁷  Tsuneji Murakami⁸ 

[1] Department of Psychiatry and Neurosciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, 734-8551, Hiroshima, Japan;Department of Psychiatry, University of Pittsburgh School of Medicine, 121 Meyran Avenue, Loeffler Building, 15260-5003, Pittsburgh, PA, USA;Japan Society for the Promotion of Science, 8 Ichiban-cho, Chiyoda-ku, 102-8472, Tokyo, Japan;Present address. Graduate School of Integrated Arts and Sciences, Tokushima University 1-1, Minamijosanjima-cho, 770-8502, Tokushima, Japan;Department of Psychiatry, University of Pittsburgh School of Medicine, 121 Meyran Avenue, Loeffler Building, 15260-5003, Pittsburgh, PA, USA;Western Psychiatric Institute and Clinic, 3811 O Hara St, 15213-2593, Pittsburgh, PA, USA;Department of Psychology, Graduate School of Education, Hiroshima University, 1-1-1 Kagamiyama, 739-8524, Higashi-Hiroshima, Hiroshima, Japan;Department of Radiology, Hiroshima City General Rehabilitation Center, 1-39-1 Tomo-minami, Asaminami-ku, 731-3168, Hiroshima, Japan;Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, 300-0051, Tsuchiura, Ibaraki, Japan;Faculty of Psychology, Otemon Gakuin University, 2-1-15 Nishiai, 567-8502, Ibaraki, Osaka, Japan;Kure Kyosai Hospital, 2-3-28 Nishi-chuo, 737-8505, Kure, Hiroshima, Japan;

关键词: Early life stress;    Amygdala reactivity;    fMRI;    Resilience;    Depression;   

DOI  :  10.1186/s12888-017-1201-x

 received in 2016-09-15, accepted in 2017-01-07,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundAmygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults.MethodsTwenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS.ResultsMood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall.ConclusionsIncreased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events.

【 授权许可】

CC BY   
© The Author(s). 2017