Abdominal obesity and other risk factors largely explain the high CRP in Indigenous Australians relative to the general population, but not gender differences: a cross-sectional study

BMC Public Health

Research Article

Jonathan Shaw¹  Allison M Hodge²  Terry Dunbar³  Joan Cunningham⁴  Jacqueline Boyle⁴  Louise Maple-Brown⁵  Tarun Weeramanthri⁶  Kerin O'Dea⁷ 

[1] Baker IDI Heart and Diabetes Institute, Melbourne, Australia;Department of Medicine, St Vincent's Hospital, University of Melbourne, Melbourne, Australia;Faculty of Education, Health and Science and Graduate School of Health Practices, Charles Darwin University, Australia;Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia;Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Darwin, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, Australia;Public Health Division, WA Health, Perth, Australia;Sansom Institute for Health Research, University of South Australia, Australia;

关键词: Waist Circumference;    High Diastolic Blood Pressure;    Indigenous Participant;    Dallas Heart Study;    Northern Territory Department;   

DOI  :  10.1186/1471-2458-10-700

 received in 2010-04-20, accepted in 2010-11-15,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundPrevious studies reported high C-reactive protein (CRP) levels in Indigenous Australians, which may contribute to their high risk of cardiovascular disease. We compared CRP levels in Indigenous Australians and the general population, accounting for obesity and other risk factors.MethodsCross-sectional study of CRP and risk factors (weight, height, waist and hip circumferences, blood pressure, lipids, blood glucose, and smoking status) in population-based samples from the Diabetes and Related conditions in Urban Indigenous people in the Darwin region (DRUID) study, and the Australian Diabetes, Obesity and Lifestyle study (AusDiab) follow-up.ResultsCRP concentrations were higher in women than men and in DRUID than AusDiab. After multivariate adjustment, including waist circumference, the odds of high CRP (>3.0 mg/L) in DRUID relative to AusDiab were no longer statistically significant, but elevated CRP was still more likely in women than men. After adjusting for BMI (instead of waist circumference) the odds for elevated CRP in DRUID participants were still higher relative to AusDiab participants among women, but not men. Lower HDL cholesterol, impaired glucose tolerance (IGT), and higher diastolic blood pressure were associated with having a high CRP in both men and women, while current smoking was associated with high CRP in men but not women.ConclusionsHigh concentrations of CRP in Indigenous participants were largely explained by other risk factors, in particular abdominal obesity. Irrespective of its independence as a risk factor, or its aetiological association with coronary heart disease (CHD), the high CRP levels in urban Indigenous women are likely to reflect increased vascular and metabolic risk. The significance of elevated CRP in Indigenous Australians should be investigated in future longitudinal studies.

【 授权许可】

CC BY   
© Hodge et al; licensee BioMed Central Ltd. 2010