'The difference in determinants of Chlamydia trachomatis and Mycoplasma genitalium in a sample of young Australian women.'

BMC Infectious Diseases

Research Article

Marian Currie¹  Francis Bowden¹  Lyle Gurrin²  Jane S Hocking³  Jennifer Walker⁴  Kathleen McNamee⁵  Catriona S Bradshaw⁶  Basil Donovan⁷  John K Kaldor⁷  Hudson Birden⁸  Jane Gunn⁹  Marie Pirotta⁹  Eve Urban^1,10  Sandra Walker^1,10  Christopher K Fairley^1,11  Marcus Y Chen^1,11  Veerakathy Harindra^1,12  Jimmy Twin^1,13  Sepehr N Tabrizi^1,13  Nicole Taylor^1,13  Suzanne Garland^1,14 

[1] Australian National University, Canberra, Australia;Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, 3010, Victoria, Australia;Centre for Women's Health, Gender and Society, School of Population Health, University of Melbourne, 3010, Victoria, Australia;Centre for Women's Health, Gender and Society, School of Population Health, University of Melbourne, 3010, Victoria, Australia;Sexual Health Unit, School of Population Health, University of Melbourne, 3010, Victoria, Australia;Family Planning Victoria, Melbourne, Australia;Monash Medical Centre. Department of Obstetrics and Gynaecology, Victoria, Clayton, Australia;Melbourne Sexual Health Centre, Alfred Health, 3010, Victoria, Melbourne, Australia;Department of Epidemiology and Preventive Medicine, Monash University, Victoria, Melbourne, Australia;National Centre in HIV Epidemiology and Clinical Research, UNSW, Sydney, Australia;North Coast Medical Education Collaboration, Sydney School of Public Health, University of Sydney, Lismore, NSW, Australia;Primary Care Research Unit, Department of General Practice, University of Melbourne, 3010, Victoria, Australia;Sexual Health Unit, School of Population Health, University of Melbourne, 3010, Victoria, Australia;Sexual Health Unit, School of Population Health, University of Melbourne, 3010, Victoria, Australia;Melbourne Sexual Health Centre, Alfred Health, 3010, Victoria, Melbourne, Australia;St Mary's Hospital, Portsmouth, UK;The Royal Women's Hospital, Victoria, Parkville, Australia;The Royal Women's Hospital, Victoria, Parkville, Australia;Department of Obstetrics and Gynaecology, University of Melbourne, 3010, Victoria, Australia;

关键词: Azithromycin;    Chlamydia Trachomatis;    Pelvic Inflammatory Disease;    Chlamydia Infection;    Partner Notification;   

DOI  :  10.1186/1471-2334-11-35

 received in 2010-08-31, accepted in 2011-02-01,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundDifferences in the determinants of Chlamydia trachomatis ('chlamydia') and Mycoplasma genitalium (MG) genital infection in women are not well understood.MethodsA cohort study of 16 to 25 year old Australian women recruited from primary health care clinics, aimed to determine chlamydia and MG prevalence and incidence. Vaginal swabs collected at recruitment were used to measure chlamydia and MG prevalence, organism-load and chlamydia-serovar a cross-sectional analysis undertaken on the baseline results is presented here.ResultsOf 1116 participants, chlamydia prevalence was 4.9% (95% CI: 2.9, 7.0) (n = 55) and MG prevalence was 2.4% (95% CI: 1.5, 3.3) (n = 27). Differences in the determinants were found - chlamydia not MG, was associated with younger age [AOR:0.9 (95% CI: 0.8, 1.0)] and recent antibiotic use [AOR:0.4 (95% CI: 0.2, 1.0)], and MG not chlamydia was associated with symptoms [AOR:2.1 (95% CI: 1.1, 4.0)]. Having two or more partners in last 12 months was more strongly associated with chlamydia [AOR:6.4 (95% CI: 3.6, 11.3)] than MG [AOR:2.2 (95% CI: 1.0, 4.6)] but unprotected sex with three or more partners was less strongly associated with chlamydia [AOR:3.1 (95%CI: 1.0, 9.5)] than MG [AOR:16.6 (95%CI: 2.0, 138.0)]. Median organism load for MG was 100 times lower (5.7 × 104/swab) than chlamydia (5.6 × 106/swab) (p < 0.01) and not associated with age or symptoms for chlamydia or MG.ConclusionsThese results demonstrate significant chlamydia and MG prevalence in Australian women, and suggest that the differences in strengths of association between numbers of sexual partners and unprotected sex and chlamydia and MG might be due to differences in the transmission dynamics between these infections.

【 授权许可】

CC BY   
© Walker et al; licensee BioMed Central Ltd. 2011