The time since last menstrual period is important as a clinical predictor for non-steroidal aromatase inhibitor-related arthralgia

BMC Cancer

Research Article

Misako Nakagawa¹  Masami Morimoto¹  Taeko Nagao¹  Miyuki Kanematsu²  Akira Tangoku²  Junko Honda²  Mitsunori Sasa³  Masako Takahashi³ 

[1] Department of Oncological and Regenerative Surgery, Institute of Health Biosciences, The University of Tokushima, 3-18-15, Kuramoto-Cho, 770-8509, Tokushima, Japan;Department of Surgery, Higashitokushima National Hospital, 1-1, Ohmukai-kita, Ootera, 779-0193, Itano, Tokushima, Japan;Department of Surgery, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, 770-0052, Tokushima, Japan;

关键词: Aromatase Inhibitor;    Carpal Tunnel Syndrome;    Carpal Tunnel;    Anastrozole;    Clinical Predictor;   

DOI  :  10.1186/1471-2407-11-436

 received in 2011-07-30, accepted in 2011-10-10,  发布年份 2011

来源: Springer

【 摘 要 】

BackgroundThe clinical predictors of aromatase inhibitor-related arthralgia (AIA), a drug-related adverse reaction of aromatase inhibitors (AIs), remain unclear.MethodsAIA was prospectively surveyed every 4 months in 328 postmenopausal breast cancer patients administered a non-steroidal AI (anastrozole). Various clinicopathological parameters were recorded and analyzed (chi-square test, Fisher's exact test and logistic regression analysis).ResultsThe mean observation period was 39.9 months. AIA manifested in 114 patients (34.8%), with peaks of onset at 4 (33.7%) and 8 months (11.4%) after starting AI administration. Some cases manifested even after 13 months. AIA tended to occur in younger patients (incidences of 46.3%, 37.4% and 28.0% for ages of < 55, 55-65 and > 65 years, respectively (p = 0.063)) and decreased significantly with the age at menarche (53.3%, 35.3% and 15.4% for < 12, 12-15 and > 15 years, respectively (p = 0.036)). The incidences were 45.1%, 46.3 and 25.1% for the time since the last menstrual period (LMP) < 5 years, 5-10 years and > 10 years, being significantly lower at > 10 years (p < 0.001). In logistic regression analysis, the AIA incidence was significantly lower in the time since LMP > 10-year group versus the < 5-year group (odds ratio 0.44, p = 0.002), but the age at menarche showed no association. AIA manifested significantly earlier (≤ 6 months) as the time since LMP became shorter (< 5 years).ConclusionAIA tends to manifest early after starting AI, but some cases show delayed onset. The incidence was significantly lower in patients with a duration of > 10 years since LMP. When the time since LMP was short, the onset of AIA was significantly earlier after starting AI administration.

【 授权许可】

Unknown   
© Kanematsu et al; licensee BioMed Central Ltd. 2011. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.