Predictors of metabolic abnormalities in phenotypes that combined anthropometric indices and triglycerides

BMC Complementary and Alternative Medicine

Research Article

Bum Ju Lee¹  Jiho Nam¹  Jong Yeol Kim¹ 

[1] KM Fundamental Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, 1672 Yuseongdae-ro, 305-811, Yuseong-gu, Deajeon, Republic of Korea;

关键词: Hypertriglyceridemic waist phenotype;    Predictor;    Machine learning;    Anthropometry;    Metabolic abnormalities;    Triglycerides;   

DOI  :  10.1186/s12906-016-1024-1

 received in 2015-04-15, accepted in 2016-01-27,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundThe hypertriglyceridemic waist (HW) phenotype has been shown to be strongly associated with metabolic abnormalities; however, to date, no study has reported the prediction of metabolic abnormalities using the HW phenotype along with waist circumference (WC) and the triglyceride (TG) level or various phenotypes consisting of an individual anthropometric index combined with the TG level. The objectives of this study were to assess the association of the HW phenotype with metabolic abnormalities in Korean women and to evaluate the predictive powers of various phenotypes with regard to metabolic abnormalities.MethodsTotal cholesterol (TC), high- and low-density lipoprotein (HDL and LDL) cholesterol, and TG levels, systolic and diastolic blood pressures (SBP and DBP), and anthropometric indices were measured in 7661 women. The Naive Bayes algorithm and logistic regression were used to determine the predictive powers of the models using different phenotypes.ResultsThe HW phenotype demonstrated the strongest association with all metabolic components. The best phenotypic predictors were the forehead-to-rib circumference ratio + TG for the HDL level, age + TG for the LDL level, age + TG for SBP, and rib circumference + TG and neck circumference + TG for DBP. The associations between TG and TC or HDL were higher compared with those between WC and TC or HDL, whereas the associations between WC and SBP or DBP were higher compared with those between TG and SBP or DBP. Age was strongly associated with hypercholesterolemia, the HDL and LDL cholesterol levels, and SBP and had good predictive power, but not with respect to DBP.ConclusionsWe have determined that the HW phenotype is a useful indicator of metabolic abnormalities in Korean women; although HW had the strongest association with metabolic abnormalities, the best phenotype combination consisting of a single anthropometric index and the TG level may differ depending on the metabolic factors in question. Our findings provide insights into the detection of metabolic abnormalities in complementary and alternative medicine.

【 授权许可】

CC BY   
© Lee et al. 2016