Major postoperative complications and survival for colon cancer elderly patients

BMC Surgery

Research Article

Giorgio Calabrese¹  Antonio Biondi²  Francesco Basile²  Giuseppe Grosso³  Antonio Mistretta³  Stefano Marventano³ 

[1] Department of Biology, Piemonte Orientale University, Alessandria, Italy;Department of General Surgery, Section of General Surgery and Oncology, University Medical School of Catania, Via Plebiscito 628, 95121, Catania, Italy;Department “G. F. Ingrassia” Section of Hygiene and Public Health, University of Catania, Via Santa Sofia 82, 95123, Catania, Italy;

关键词: Elderly Patient;    Postoperative Complication;    Increase Life Expectancy;    Confidential Interval;    Pelvic Abscess;   

DOI  :  10.1186/1471-2482-12-S1-S20

来源: Springer

【 摘 要 】

BackgroundIncreased life expectancy has led to elevating the mean age of the patients at the time of diagnosis of colon cancer and subsequent treatment. Differences in complication rates and outcome between elderly and younger patients have been investigated.MethodsWe retrospectively analysed a database containing the information of patients who underwent surgery for stage I-III colorectal cancer from January 2004 to January 2012 at our institution and compared demographic, cancer-related, and outcomes data of 235 elderly patients with 211 patients ≤65 years old.ResultsIntraoperative complications did not differ between young and old patients whereas some differences have been found in postoperative and late complications: elderly patients suffered more by ileus (P = 0.024), peritonitis or septic shock (P = 0.017), pelvic abscess (P = 0.028), wound infection (P = 0.031), and incisional/port herniation (P = 0.012) compared with younger patients. Moreover, elderly patients suffered by systemic complications such as cardiovascular (4.7% vs. 1.4%, P = 0.049), renal (4.7% vs. 0.5%, P = 0.006), and respiratory (10.6% vs. 5.2%, P = 0.036). The multivariate analysis assessing the odds of having a complication revealed that older age (Odd Ratio [OR] 2.75, 95% Confidential Interval [CI]: 1.67-4.52) and open surgery (OR 1.63, 95% CI: 1.01-2.62) are significantly and independently associated with having a complication.ConclusionsIn our series, elderly patients have presented a slight higher incidence of comorbidities that may affect the incidence rates of postoperative complications. These results have implications in increasing the hospital stay as well as a higher rate of death.

【 授权许可】

Unknown   
© Grosso et al; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.