BMC Psychiatry | |
Association of body mass index with amnestic and non-amnestic mild cognitive impairment risk in elderly | |
Research Article | |
Minghui Zhao1  Zhaoli Han1  Yongqiang Zhang1  Shishuang Zhang1  Feng Wang1  Ning Sun1  Qiang Zhang1  Dai Li1  Xiaodong Kong1  Ping Lei1  | |
[1] Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Geriatrics Institute, No. 154, Anshan Road, Heping District, 300052, Tianjin, China; | |
关键词: Body mass index; Dementia; Mild cognitive impairment; Obesity; Weight; | |
DOI : 10.1186/s12888-017-1493-x | |
received in 2017-04-19, accepted in 2017-09-06, 发布年份 2017 | |
来源: Springer | |
【 摘 要 】
BackgroundPrevious studies focused on the relationship between body mass index and cognitive disorder and obtained many conflicting results. This study explored the potential effects of body mass index on the risk of mild cognitive impairment (amnestic and non-amnestic) in the elderly.MethodsThe study enrolled 240 amnestic mild cognitive impairment patients, 240 non-amnestic mild cognitive impairment patients and 480 normal cognitive function controls. Data on admission and retrospective data at baseline (6 years ago) were collected from their medical records. Cognitive function was evaluated using Mini-Mental State Examination and Montreal Cognitive Assessment.ResultsBeing underweight, overweight or obese at baseline was associated with an increased risk of amnestic mild cognitive impairment (OR: 2.30, 95%CI: 1.50 ~ 3.52; OR: 1.74, 95%CI: 1.36 ~ 2.20; OR: 1.71, 95%CI: 1.32 ~ 2.22, respectively). Being overweight or obese at baseline was also associated with an increased risk of non-amnestic mild cognitive impairment (OR: 1.51, 95%CI: 1.20 ~ 1.92; OR: 1.52, 95%CI: 1.21 ~ 1.97, respectively). In subjects with normal weights at baseline, an increased or decreased body mass index at follow-up was associated with an elevated risk of amnestic mild cognitive impairment (OR: 1.80, 95%CI: 1.10 ~ 3.05; OR: 3.96, 95%CI: 2.88 ~ 5.49, respectively), but only an increased body mass index was associated with an elevated risk of non-amnestic mild cognitive impairment (OR: 1.71, 95%CI: 1.16 ~ 2.59).ConclusionsUnhealthy body mass index levels at baseline and follow-up might impact the risk of both types of mild cognitive impairment (amnestic and non-amnestic).
【 授权许可】
CC BY
© The Author(s). 2017
【 预 览 】
Files | Size | Format | View |
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RO202311090259383ZK.pdf | 369KB | download |
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