Comparison of artificial graft versus autograft in anterior cruciate ligament reconstruction: a meta-analysis

BMC Musculoskeletal Disorders

Research Article

Shi-qi Cao¹  Tian-ze Liu²  Chen-chen Xue²  Chen Zhang²  Wei-Dong Xu²  Zhen-Yu Jia²  Xuan Huang² 

[1] Department of Joint Surgery and Sports Medicine, Changzheng Hospital, Shanghai, China;Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China;

关键词: Artificial ligament;    Autograft;    Anterior cruciate ligament;    Reconstruction;   

DOI  :  10.1186/s12891-017-1672-4

 received in 2017-03-19, accepted in 2017-07-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCritically evaluation and summarization for the outcomes between autografts and artificial grafts using in anterior cruciate ligament (ACL) reconstruction have not been performed currently. The purpose of this study is to compare the clinical outcomes between artificial ligaments and autografts at a short- to mid-term follow-up.MethodsA computerized search of the databases was conducted including Medline, Embase, and the Cochrane library. Only prospective or retrospective comparative studies with a minimum 2-year follow-up and a minimum sample size of 15 for each group were considered for inclusion. Two independent reviewers performed data extraction and methodological quality assessment. A Mantel-Haenszel analysis was used for pooling of results. Sensitivity analysis was performed in order to maintain the stability of results.ResultsSeven studies were included in this study. The total sample size was 403 (autograft group: 206 patients; synthetic graft group: 197 patients). Four studies were randomized controlled trials. Two studies were retrospective comparative studies and one study was non-randomized prospective comparative study. In terms of instrumented laxity, patient-oriented outcomes and complications, no significant difference was occurred between new artificial ligaments and autografts. But the results of IKDC grades and instrumented laxity were worsen in early artificial ligaments compared to autografts.ConclusionsThe outcomes of new generation of artificial ligaments are similar to autografts at a short- to mid-term follow-up. However, the early artificial ligaments are not suggested for ACL reconstruction compared to autografts.

【 授权许可】

CC BY   
© The Author(s). 2017