期刊论文详细信息
BMC Ophthalmology
Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser speckle flowgraphy
Research Article
Yukihiro Shiga1  Yu Yokoyama1  Naoko Aizawa1  Kazuko Omodaka1  Hiroshi Kunikata2  Toru Nakazawa3 
[1] Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, 980-8574, Aoba-ku, Sendai, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, 980-8574, Aoba-ku, Sendai, Japan;Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan;Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, 980-8574, Aoba-ku, Sendai, Japan;Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan;Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan;
关键词: Laser speckle flowgraphy;    Glaucoma;    Myopia;    Myopic disc;    Retinal nerve fiber layer;    Optic nerve blood flow;   
DOI  :  10.1186/1471-2415-14-113
 received in 2014-05-08, accepted in 2014-09-10,  发布年份 2014
来源: Springer
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【 摘 要 】

BackgroundIt is difficult to identify glaucoma in myopic eyes because the configuration of the optic disc varies; yet it is important clinically. Here, we used laser speckle flowgraphy (LSFG) to measure mean blur rate (MBR), representing optic disc microcirculation, and assessed its ability to identify glaucoma in eyes with myopic optic discs.Methods129 eyes (normal disc: 21 eyes; myopic disc: 108 eyes) were enrolled. The eyes were classified as normal or mildly, moderately, or severely glaucomatous with standard automated perimetry (SAP). We determined the relationship between optic nerve head (ONH) MBR, measured with LSFG, mean deviation (MD), measured with SAP, and circumpapillary retinal nerve fiber layer thickness (cpRNFLT), measured with optical coherence tomography (OCT).ResultsONH MBR and cpRNFLT decreased significantly with the severity of glaucoma. MBR was significantly correlated with cpRNFLT and MD (r =0.65 and r =0.63, respectively). A multiple regression analysis revealed that MBR and cpRNFLT were independent factors indicating glaucoma severity. A logistic regression analysis revealed that MBR and cpRNFLT were also independent factors indicating the presence of glaucoma. In a receiver operating characteristic (ROC) analysis, MBR and cpRNFLT could both differentiate between normal and glaucomatous eyes (MBR area under the ROC curve: 0.86, with a cut-off score of 24.0 AU).ConclusionThese results suggest that in addition to cpRNFLT, non-invasive and objective LSFG measurements of MBR may enable the identification of glaucoma and the classification of its severity in eyes with myopic optic discs.

【 授权许可】

Unknown   
© Aizawa et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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