Are sleep disorders associated with increased mortality in asthma patients?

BMC Pulmonary Medicine

Research Article

Kyu-Tae Han¹  Woorim Kim¹  Yeong Jun Ju¹  Hyo Jung Lee¹  Seung Ju Kim¹  Eun-Cheol Park²  Hong-Chul Bae³  Sang Gyu Lee⁴ 

[1] Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea;Institute of Health Services Research, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea;Institute of Health Services Research, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea;Office of Communication, Korea Centers for Disease Control and Prevention, Cheongju, Republic of Korea;Institute of Health Services Research, Yonsei University College of Medicine, Seoul, Republic of Korea;Department of Hospital Management, Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea;

关键词: Sleep disorders;    Asthma;    Mortality;    Healthcare accessibility;    Vulnerable population;   

DOI  :  10.1186/s12890-016-0313-2

 received in 2016-03-23, accepted in 2016-11-07,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundSouth Korea has experienced problems regarding poor management of symptoms of asthma patients and remarkable increases in sleep disorders. However, few studies have investigated these issues. We examined the relationship between sleep disorders and mortality in asthma patients to suggest effective alternatives from a novel perspective.MethodsWe used data from the National Health Insurance Service (NHIS) National Sample Cohort 2004–2013, which included medical claims filed for 186,491 patients who were newly diagnosed with asthma during the study period. We performed survival analyses using a Cox proportional hazards model with time-dependent covariates to examine the relationship between sleep disorders and mortality in asthma patients.ResultsThere were 5179 (2.78%) patients who died during the study period. Sleep disorders in patients previously diagnosed with asthma were associated with a higher risk of mortality (hazard ratio [HR]: 1.451, 95% confidence interval [CI]: 1.253–1.681). In addition, significant interaction was found between sleep disorders and Charlson comorbidity index.ConclusionsOur findings suggest that an increased prevalence of sleep disorders in asthma patients increases the risk of mortality. Considering the worsening status of asthma management and the rapid growth of sleep disorders in South Korea, clinicians and health policymakers should work to develop interventions to address these issues.

【 授权许可】

CC BY   
© The Author(s). 2016