Chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco

BMC Urology

Research Article

Chadli Elbekkay¹  Lunda Razoki¹  Brahim El Houate²  Abdelhamid Barakat²  Hassan Rouba²  Hicham Charoute²  Yassine Naasse³  Abderrahim Malki⁴ 

[1] Laboratoire de Cytogénétique, Département de la Recherche Scientifique, Institut Pasteur du Maroc, 1 Place Louis Pasteur, 20360, Casablanca, Morocco;Laboratoire de Génétique Moléculaire Humaine, Département de la Recherche Scientifique, Institut Pasteur du Maroc, 1 Place Louis Pasteur, 20360, Casablanca, Morocco;Laboratoire de Génétique Moléculaire Humaine, Département de la Recherche Scientifique, Institut Pasteur du Maroc, 1 Place Louis Pasteur, 20360, Casablanca, Morocco;Laboratoire de Physiopathologie et Génétique Moléculaire, Faculté des Sciences Ben M’Sik, Université Hassan II, Casablanca, Morocco;Laboratoire de Physiopathologie et Génétique Moléculaire, Faculté des Sciences Ben M’Sik, Université Hassan II, Casablanca, Morocco;

关键词: Male infertility;    Chromosomal abnormalities;    Y microdeletions;    Severe oligozoospermia;    Azoospermia;   

DOI  :  10.1186/s12894-015-0089-3

 received in 2015-04-30, accepted in 2015-09-10,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMale infertility is responsible for 50 % of infertile couples. Thirty percent of male infertility is due to cytogenetic and genetic abnormalities. In Arab and North African populations, several studies have shown the association of these chromosomal abnormalities with male infertility. Our objective is to evaluate the frequency of chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco.MethodsA total of 573 Moroccan infertile men (444 azoospermic and 129 oligozoospermic men) referred for cytogenetic analysis to the Department of Cytogenetics of the Pasteur Institute of Morocco, were screened for the presence of chromosomal abnormalities and Y chromosome microdeletions.ResultsChromosomal abnormalities accounted for approximately 10.5 % (60/573). Fifty six cases among them have sex chromosome abnormalities (93.34 %), including Klinefelter’s syndrome in 41 patients (68.34 %). Autosomal chromosome abnormalities (6.66 %) were observed in 4 patients. Chromosomal abnormalities were more prevalent in azoospermic men (13.06 %) than in oligospermic men (1.55 %). Y microdeletions were detected in 16 of 85 patients (AZFc: 14.12 %, AZFbc: 4.70 %), most of them where azoospermic men with no chromosomal abnormality.ConclusionsThese results highlighted the need for efficient molecular genetic testing in male infertility diagnosis. In addition, a genetic screening should be performed in infertile men before starting assisted reproductive treatments.

【 授权许可】

CC BY   
© Naasse et al. 2015