Gender differences of cognitive function in migraine patients: evidence from event-related potentials using the oddball paradigm

The Journal of Headache and Pain

Research Article

Rongfei Wang¹  Xiaoyan Chen¹  Mingjie Zhang¹  Weiquan Jia¹  Shengyuan Yu¹  Xiaolan Zhang¹  Fan Yang¹  Zhao Dong¹ 

[1] Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, Haidian District, 100853, Beijing, China;

关键词: Migraine;    ERPs;    P3;    N2;    Gender difference;   

DOI  :  10.1186/1129-2377-15-6

 received in 2013-11-15, accepted in 2014-01-20,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMigraine shows gender-specific incidence and has a higher prevalence in females. Gender plays an important role in the prevalence of migraine, but few studies have investigated the effect of gender on the cognitive functions of migraine patients. This study investigated gender differences in the cognitive function of migraine patients without aura.MethodsWe recruited 29 migraine patients (15 females; mean age 25.4 y) during the interictal period and 28 healthy age-matched participants (14 females; mean age 24.8 y). We used an auditory oddball paradigm to analyze target processing using event-related potentials.ResultsWe investigated the N2 and P3 components. The P3 amplitude was decreased in patients compared with the control, and this reduction was not modulated by gender. These results of the P3 provided a new evidence for the dysfunction of cognitive function in migraine patients. The N2 amplitude was larger for male than female migraine patients, and this gender effect was not found in the control group.ConclusionsThese results of the P3 provided a new evidence for the dysfunction of cognitive function in migraine patients. And those of N2 may explain that male patients have the super-sensitivity of cerebral function relevant to the early target-selection and response preparation. Our findings emphasize the importance of considering gender when researching the cognitive function of migraine patients.

【 授权许可】

Unknown   
© Wang et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.