The impacts of migraine and anxiety disorders on painful physical symptoms among patients with major depressive disorder

The Journal of Headache and Pain

Research Article

Shuu-Jiun Wang¹  Ching-Hui Yang²  Chia-Yih Liu³  Ching-Yen Chen³  Ching-I Hung³ 

[1] Department of Neurology, National Yang-Ming University School of Medicine and Taipei Veterans General Hospital, No. 201 Shi-Pai Road, Section 2, Taipei 112, Taiwan;Department of Nursing, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan;Department of Psychiatry, Chang-Gung Memorial Hospital at Linkou and Chang-Gung University College of Medicine, Tao-Yuan, Taiwan;

关键词: Depression;    Anxiety;    Headache;    Pain;    Somatization;    Prognosis;   

DOI  :  10.1186/1129-2377-15-73

 received in 2014-09-23, accepted in 2014-11-03,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundNo study has simultaneously investigated the impacts of migraine and anxiety disorders on painful physical symptoms (PPS) among patients with major depressive disorder (MDD). The study aimed to investigate this issue.MethodsThis open-label study enrolled 155 outpatients with MDD, who were then treated with venlafaxine 75 mg per day for four weeks. Eighty-five participants with good compliance completed the treatment. Migraine was diagnosed according to the International Classification of Headache Disorders. MDD and anxiety disorders were diagnosed using the Structured Clinical Interview for DSM-IV-TR. The visual analog scale (VAS) was used to evaluate the severity of eight PPS. Multiple linear and logistic regressions were used to investigate the impacts of migraine and anxiety disorders on PPS.ResultsCompared with patients without migraine, patients with migraine had a greater severity of PPS at baseline and post-treatment. After controlling for demographic variables and depressive severity, migraine independently predicted the intensities of eight PPS at baseline and four PPS post-treatment. Moreover, migraine independently predicted poorer treatment responses of chest pain and full remission of pains in the head, chest, neck and/or shoulder. Anxiety disorders predicted less full remission of pains in the abdomen and limbs.ConclusionMigraine and anxiety disorders have negative impacts on PPS among patients with MDD. Integrating the treatment of migraine and anxiety disorders into the management of depression might help to improve PPS and the prognosis of MDD.

【 授权许可】

Unknown   
© Hung et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.