Does visual cortex lactate increase following photic stimulation in migraine without aura patients? A functional 1H-MRS study

The Journal of Headache and Pain

Original

Koen Paemeleire¹  Anneloor Dierickx²  Eric Achten²  Pieter Vandemaele²  Benedicte Descamps²  Harmen Reyngoudt²  Yves De Deene³ 

[1] Department of Basic Medical Sciences, Ghent University, Ghent, Belgium;Department of Neurology, Ghent University Hospital, Ghent, Belgium;Department of Radiology and Nuclear Medicine, MR-department (−1K12B), Ghent University Hospital, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium;Ghent Institute for Functional and Metabolic Imaging, Ghent University Hospital, Ghent, Belgium;Laboratory for qNMR in Medicine and Biology, Ghent University, Ghent, Belgium;Department of Nuclear Medicine and Radiobiology, Sherbrooke University, Sherbrooke, QC, Canada;

关键词: Migraine without aura;    Functional H-MRS;    Lactate;    Visual cortex;    Absolute quantification;   

DOI  :  10.1007/s10194-011-0295-7

 received in 2010-12-10, accepted in 2011-01-09,  发布年份 2011

来源: Springer

【 摘 要 】

Proton magnetic resonance spectroscopy (1H-MRS) has been used in a number of studies to assess noninvasively the temporal changes of lactate (Lac) in the activated human brain. Migraine neurobiology involves lack of cortical habituation to repetitive stimuli and a mitochondrial component has been put forward. Our group has recently demonstrated a reduction in the high-energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr) in the occipital lobe of migraine without aura (MwoA) patients, at least in a subgroup, in a phosphorus MRS (31P-MRS) study. In previous studies, basal Lac levels or photic stimulation (PS)-induced Lac levels were found to be increased in patients with migraine with aura (MwA) and migraine patients with visual symptoms and paraesthesia, paresia and/or dysphasia, respectively. The aim of this study was to perform functional 1H-MRS at 3 T in 20 MwoA patients and 20 control subjects. Repetitive visual stimulation was applied using MR-compatible goggles with 8 Hz checkerboard stimulation during 12 min. We did not observe any significant differences in signal integrals, ratios and absolute metabolite concentrations, including Lac, between MwoA patients and controls before PS. Lac also did not increase significantly during and following PS, both for MwoA patients and controls. Subtle Lac changes, smaller than the sensitivity threshold (i.e. estimated at 0.1–0.2 μmol/g at 3 T), cannot be detected by MRS. Our study does, however, argue against a significant switch to non-aerobic glucose metabolism during long-lasting PS of the visual cortex in MwoA patients.

【 授权许可】

CC BY   
© The Author(s) 2011