The serotonin transporter gene polymorphism is associated with the susceptibility and the pain severity in Idiopathic Trigeminal Neuralgia patients

The Journal of Headache and Pain

Research Article

Xue Yu¹  Huiqian Zhang¹  Wenyao Cui¹ 

[1]Department of Anesthesiology, The First Affiliated Hospital, China Medical University, NO.155 of Nanjingbei Street, Heping District, 110001, Shenyang, Liaoning Province, People’s Republic of China

关键词: Serotonin transporter;    Trigeminal Neuralgia;    Susceptibility;    Chinese;   

DOI  :  10.1186/1129-2377-15-42

 received in 2014-05-07, accepted in 2014-05-29,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundTo investigate the possible association between the serotonin transporter gene (5-HTTLPR) and rs 25531 polymorphism and the susceptibility and the pain severity in Trigeminal Neuralgia patients.MethodsA total of 244 TN patients and 280 age and sex matched healthy volunteer were recruited. 5-HTTLPR and rs 25531 genotyping were performed. All patients received the carbamazepine treatment and the treatment response was evaluated at 6 months.ResultsThe genotype distribution of 5-HTTLPR between TN patients and controls were significantly different. The TN Patients had a higher prevalence of short-short genotype than controls. The short-short genotype carriers are also significantly associated with higher pain severity and poorer carbamazepine treatment response compared to the long-long genotype carriers. In contrast, the rs 25531 polymorphism was not associated with the susceptibility to TN, neither with the pain severity and the treat response to carbamazepine.ConclusionThe 5-HTTLPR polymorphism is associated with the susceptibility to TN and pain severity of TN.

【 授权许可】

CC BY   
© Cui et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.