The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

The Journal of Headache and Pain

Review Article

Johanne Severinsen¹  Messoud Ashina¹  Mohammad Al-Mahdi Al-Karagholi¹  Jakob Møller Hansen¹  Inger Jansen-Olesen² 

[1] Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Nordre Ringvej 57, DK-2600, Copenhagen, Denmark;Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Nordre Ringvej 57, DK-2600, Copenhagen, Denmark;Danish Headache Center, Department of Neurology, Glostrup Research Park, Rigshospitalet Glostrup, Copenhagen, Denmark;

关键词: Migraine;    K channel;    K channels;    Headache;    Levcromakalim;    Cromakalim;   

DOI  :  10.1186/s10194-017-0800-8

 received in 2017-07-03, accepted in 2017-08-15,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundTo review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.DiscussionKATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.ConclusionWe suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

【 授权许可】

CC BY   
© The Author(s). 2017