Migraine, arousal and sleep deprivation: comment on: “sleep quality, arousal and pain thresholds in migraineurs: a blinded controlled polysomnographic study”

The Journal of Headache and Pain

Letter to the Editor

Elisa Testani¹  Catello Vollono¹  Anna Losurdo¹  Salvatore Mazza¹  Giacomo Della Marca¹ 

[1] Institute of Neurology, Catholic University, Policlinico Universitario ‘A. Gemelli’, Largo A. Gemelli, 8-00168, Rome, Italy;

关键词: Migraine;    Sleep;    Sleep deprivation;    Cyclic alternating pattern;    Arousal;    Pain;   

DOI  :  10.1186/1129-2377-14-50

 received in 2013-05-11, accepted in 2013-05-29,  发布年份 2013

来源: Springer

【 摘 要 】

We discuss the hypothesis proposed by Engstrom and coworkers that Migraineurs have a relative sleep deprivation, which lowers the pain threshold and predispose to attacks. Previous data indicate that Migraineurs have a reduction of Cyclic Alternating Pattern (CAP), an essential mechanism of NREM sleep regulation which allows to dump the effect of incoming disruptive stimuli, and to protect sleep. The modifications of CAP observed in Migraineurs are similar to those observed in patients with impaired arousal (narcolepsy) and after sleep deprivation. The impairment of this mechanism makes Migraineurs more vulnerable to stimuli triggering attacks during sleep, and represents part of a more general vulnerability to incoming stimuli.

【 授权许可】

Unknown   
© Vollono et al.; licensee Springer. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.