The Journal of Headache and Pain | |
Release of PACAP-38 in episodic cluster headache patients – an exploratory study | |
Short Report | |
Lars Edvinsson1  Eszter Tóth2  Nikoletta Szabó2  Zsigmond Tamás Kincses2  Tamás Körtési2  János Tajti2  Délia Szok2  Árpád Párdutz2  Bernadett Tuka3  László Vécsei3  Teréz Bagoly4  Zsuzsanna Helyes5  | |
[1] Department of Clinical Sciences, Division of Experimental Vascular Research, Lund University, Sölvegatan 17, BMC A13, 22184, Lund, Sweden;Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725, Szeged, Hungary;Department of Neurology, Faculty of Medicine, University of Szeged, Semmelweis u. 6, H-6725, Szeged, Hungary;MTA-SZTE Neuroscience Research Group, Semmelweis u. 6, H-6725, Szeged, Hungary;Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Szigeti u. 12, H-7624, Pécs, Hungary;Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pécs, Szigeti u. 12, H-7624, Pécs, Hungary;János Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624, Pécs, Hungary;MTA-PTE NAP B Pain Research Group, University of Pécs, Szigeti u. 12, H-7624, Pécs, Hungary; | |
关键词: Episodic cluster headache; Plasma PACAP-38-LI; Inter-bout period; Ictal phase; | |
DOI : 10.1186/s10194-016-0660-7 | |
received in 2016-05-22, accepted in 2016-07-22, 发布年份 2016 | |
来源: Springer | |
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【 摘 要 】
BackgroundActivation of the trigeminal-autonomic reflex, involving the trigeminal ganglion, the superior salivatory nucleus and the sphenopalatine ganglion (SPG) is crucial in the pathophysiology of cluster headache (CH). Since pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) is present both in the SPG and the trigeminal ganglion (TG) and its role in migraine has been described, our aim was to determine the plasma PACAP-38 levels in different phases of episodic CH (ECH).Peripheral cubital fossa blood samples were taken during the ictal and inter-bout periods of male ECH patients and from age-matched healthy controls (n = 9). Plasma PACAP-38-like immunoreactivity (LI) was measured with specific and sensitive radioimmunoassay.FindingsSignificantly lower plasma PACAP-38-LI was detected in the inter-bout period of ECH patients than in healthy controls. However, PACAP-38 was significantly elevated in the plasma during CH attacks as compared to the inter-bout phase in the same subjects (n = 5).ConclusionsThis exploratory study suggests that PACAP-38 may be released during the attacks of ECH. Further patients and long-term follow-up are necessary to reveal its function.
【 授权许可】
CC BY
© The Author(s). 2016
【 预 览 】
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