Osmophobia and allodynia are critical factors for suicidality in patients with migraine

The Journal of Headache and Pain

Research Article

Won-Kee Lee¹  Jong-Geun Seo²  Sung-Pa Park² 

[1] Center of Biostatics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea;Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, 700-842, Daegu, Republic of Korea;

关键词: Suicide;    Osmophobia;    Allodynia;    Migraine;    Risk factor;    Depression;    Anxiety;   

DOI  :  10.1186/s10194-015-0529-1

 received in 2015-03-26, accepted in 2015-05-04,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundSensory hypersensitivities are common phenomena in migraine. We examined the role of sensory hypersensitivities on suicidality in patients with migraine.MethodsPatients with migraine (with or without aura) were consecutively recruited from our headache clinic. We asked them if they experienced photophobia, phonophobia, osmophobia, and allodynia during migraine attack. The Mini International Neuropsychiatric Interview was used to diagnose current major depressive disorder (MDD), current generalized anxiety disorder (GAD) and suicidality.ResultsAmong 220 subjects, 25.5 % had current MDD, 17.3 % had current GAD, and 31.8 % had suicidality. Patients with suicidality were more like to have a low household income, chronic migraine (CM), medication overuse headache, high headache intensity, osmophobia, allodynia, high disability, MDD, and GAD than those without suicidality. The strongest risk factor for suicidality by multivariate analyses was osmophobia (adjusted Odds Ratio [AOR] 3.12, 95 % confidence interval [CI] 1.57-6.21, p = 0.001), followed by current MDD (AOR 2.99, 95 % CI 1.33-6.76, p = 0.008), CM (AOR 2.48, 95 % CI 1.21-5.09, p = 0.013), current GAD (AOR 3.11, 95 % CI 1.22-7.91, p = 0.017), and allodynia (AOR 2.72, 95 % CI 1.19-6.21, p = 0.018).ConclusionsOsmophobia and allodynia are critical factors for suicidality in patients with migraine, after controlling for depression, anxiety, and CM.

【 授权许可】

CC BY   
© Park et al.; licensee Springer. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.