Validation of the Patient Health Questionnaire-9 (PHQ-9) and PHQ-2 in patients with migraine

The Journal of Headache and Pain

Research Article

Jong-Geun Seo¹  Sung-Pa Park¹ 

[1] Department of Neurology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, 700-842, Daegu, Republic of Korea;

关键词: Depression;    Migraine;    PHQ-9;    PHQ-2;    Validity;   

DOI  :  10.1186/s10194-015-0552-2

 received in 2015-05-19, accepted in 2015-07-04,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundPsychiatric problems have been commonly reported in patients with migraine. This study investigated the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) and Patient Health Questionnaire-9 (PHQ-2) in patients with migraine.MethodsPatients with migraine (with or without aura) were consecutively recruited from our headache clinic. They completed several instruments, including the Mini International Neuropsychiatric Interview-Plus Version 5.0.0 (MINI), the PHQ-9, the Beck Depression Inventory-II (BDI-II), the Migraine Disability Assessment Scale (MIDAS), the Headache Impact Test-6 (HIT-6), and the Migraine-Specific Quality of Life (MSQoL).ResultsAmong 132 participants, 39 patients (29.5 %) had a major depressive disorder (MDD) as determined by the MINI. Cronbach’s α coefficients for the PHQ-9 and PHQ-2 were 0.894 and 0.747, respectively. At a cutoff score of 7, the PHQ-9 had a sensitivity of 79.5 %, a specificity of 81.7 %, a positive predictive value (PPV) of 64.6 %, and a negative predictive value (NPV) of 90.5 %. At a cutoff score of 2, the PHQ-2 had a sensitivity of 66.7 %, a specificity of 90.3 %, a PPV of 74.3 %, and a NPV of 86.6 %. The scores of the PHQ-9 and PHQ-2 well correlated with the BDI-II score, the MIDAS score, the HIT-6 score, and the MSQoL score.ConclusionsThe PHQ-9 and PHQ-2 are both reliable and valid screening instruments for MDD in patients with migraine.

【 授权许可】

CC BY   
© Seo and Park. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.