Resting state brain activity in patients with migraine: a magnetoencephalography study

The Journal of Headache and Pain

Research Article

Huaiting Ge¹  Ailiang Miao¹  Xiaoshan Wang¹  Lu Tang¹  Hongxing Liu¹  Jing Xiang²  Lu Yang³  Ting Wu³  Qiqi Chen³ 

[1] The Department of Neurology, Nanjing Brain Hospital, Nanjing Medical University, Guang Zhou Road 264, 210029, Nanjing, Jiangsu, China;The MEG Center, Division of Neurology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, 45220, Cincinnati, OH, USA;The MEG Center, Nanjing Brain Hospital, Nanjing, Jiangsu, China;

关键词: Migraine;    Magnetoencephalography (MEG);    Mufti-frequency;    Ictal activity;   

DOI  :  10.1186/s10194-015-0525-5

 received in 2015-02-11, accepted in 2015-04-25,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundRecent advances in migraine research have shown that the cerebral cortex serves a primary role in the pathogenesis of migraine. Since aberrant brain activity in migraine can be noninvasively detected with magnetoencephalography (MEG), The object of this study was to investigate the resting state cortical activity differences between migraineurs and controls and its related clinical characteristics.MethodsTwenty-two subjects with an acute migraine and twenty-two age- and gender-matched controls were studied using MEG. MEG recordings were recorded 120 seconds during the headache attack. Analyze MEG signals from low (1–4 Hz) to high (200–1000 Hz)-frequency ranges.ResultsIn comparison with the controls, brain activity in migraine subjects was significantly different from that of the controls both in two frequency ranges (55–90 Hz, p < 0.001) and (90–200 Hz, p < 0.004). But the power value showed no significantly differences between control and migraines in all frequency ranges (p > 0.05). All the clinical characteristics had no significant correlation with aberrant brain activity.ConclusionsThe results demonstrated that migraine subjects in resting state had significantly aberrant ictal brain activity that can be measured with neuromagnetic imaging techniques. The findings may facilitate the development of new therapeutic strategies in migraine treatment via alterations in cortical excitability with TMS and other medications in the future.

【 授权许可】

Unknown   
© Liu et al.; licensee Springer. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.