Interictal burden attributable to episodic headache: findings from the Eurolight project

The Journal of Headache and Pain

Research Article

Elena Ruiz de la Torre¹  Michel Lantéri-Minet²  Jose Miguel Laínez³  Zaza Katsarava⁴  Hallie Thomas⁵  Timothy J. Steiner⁶  Lars Jacob Stovner⁷  Colette Andrée⁸  Christian Lampl⁹  Cristina Tassorelli^1,10  Daiva Rastenyte^1,11 

[1] Asociacion Española de Pacientes con Cefalea (AEPAC), Valencia, Spain;Departement d’Evaluation et Traitement de la Douleur, Centre Hospitalo-Universitaire de Nice, Nice, France;INSERM/UdA, U1107, Neuro-Dol, Clermont-Ferrand, France;Department of Neurology, Hospital Clinico Universitario, University of Valencia, Valencia, Spain;Department of Neurology, University of Duisberg-Essen, Essen, Germany;Department of Neurology, Evangelical Hospital Unna, Unna, Germany;Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway;Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway;Division of Brain Sciences, Imperial College London, London, UK;Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway;Norwegian Advisory Unit on Headache, St Olavs University Hospital, Trondheim, Norway;Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland;Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg;Headache Medical Center, Linz, Austria;Department of Neurogeriatric Medicine and Remobilisation, Hospital of the Sisters of Charity, Linz, Austria;Headache Science Centre, C Mondino National Neurological Institute, Pavia, Italy;Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy;Lithuanian University of Health Sciences, Kaunas, Lithuania;

关键词: Headache;    Migraine;    Tension-type headache;    Interictal burden;    Public health;    Europe;    Eurolight project;    Global Campaign against Headache;   

DOI  :  10.1186/s10194-016-0599-8

 received in 2015-12-03, accepted in 2016-02-02,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundMost primary headaches are episodic, and most estimates of the heavy disability burden attributed to headache derive from epidemiological data focused on the episodic subtypes of migraine and tension-type headache (TTH). These disorders give rise directly but intermittently to symptom burden. Nevertheless, people with these disorders may not be symptom-free between attacks. We analysed the Eurolight dataset for interictal burden.MethodsEurolight was a cross-sectional survey using modified cluster sampling from the adult population (18–65 years) in 10 countries of the European Union. We used data from nine. The questionnaire included headache-diagnostic questions based on ICHD-II and several question sets addressing impact, including interictal and cumulative burdens.ResultsThere were 6455 participants with headache (male 2444 [37.9 %]). Interictal symptoms were reported by 26.0 % of those with migraine and 18.9 % with TTH: interictal anxiety by 10.6 % with migraine and avoidance (lifestyle compromise) by 14.8 %, both much more common than in TTH (3.1 % [OR 3.8] and 4.7 % [OR 3.5] respectively). Mean time spent in the interictal state was 317 days/year for migraine, 331 days/year for TTH. Those who were “rarely” or “never” in control of their headaches (migraine 15.2 %, TTH 9.6 %) had significantly raised odds of interictal anxiety, avoidance and other interictal symptoms. Among those with migraine, interictal anxiety increased markedly with headache intensity and frequency, avoidance less so but still significantly. Lost productive time was associated with high ORs (up to 5.3) of anxiety and avoidance.A third (32.9 %) with migraine and a quarter (26.7 %) with TTH (difference: p < 0.0001) were reluctant to tell others of their headaches. About 10 % with each disorder felt families and friends did not understand their headaches. Nearly 12 % with migraine reported their employers and colleagues did not.Regarding cumulative burden, 11.8 % reported they had done less well in education because of headache, 5.9 % reported reduced earnings and 7.4 % that their careers had suffered.ConclusionsInterictal burden in those with episodic headache is common, more so in migraine than TTH. Some elements have the potential to be profoundly consequential. New methodology is needed to measure interictal burden if descriptions of headache burden are to be complete.

【 授权许可】

CC BY   
© Lampl et al. 2016