Contraceptive-induced amenorrhoea leads to reduced migraine frequency in women with menstrual migraine without aura

The Journal of Headache and Pain

Short Report

E Anne MacGregor¹  Kjersti Grøtta Vetvik²  Michael Bjørn Russell²  Christofer Lundqvist³ 

[1] Centre for Neuroscience and Trauma, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, UK;Head and Neck Research Group, Research Centre, Akershus University hospital, 1478, Lørenskog, Norway;Institute of Clinical Medicine, Campus Akershus University Hospital, University of Oslo, Oslo, Norway;Head and Neck Research Group, Research Centre, Akershus University hospital, 1478, Lørenskog, Norway;Institute of Clinical Medicine, Campus Akershus University Hospital, University of Oslo, Oslo, Norway;HØKH, Research Centre, Akershus University Hospital, 1478, Lørenskog, Norway;Department of Neurology, Akershus University Hospital, 1478, Lørenskog, Norway;

关键词: Menstrual migraine without aura;    Migraine;    Amenorrhoea;    Contraception;    Hormones;    Estrogen;    Progestin;    Prostaglandins;    Ovulation;   

DOI  :  10.1186/1129-2377-15-30

 received in 2014-02-26, accepted in 2014-05-07,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundMenstrual migraine without aura (MM) affects approximately 20% of female migraineurs in the general population. The aim of the present study was to investigate the influence of contraception on the attacks of migraine without aura (MO) in women with MM.Findings141 women from the general population with a history of MM according to the International Classification of Headache Disorders II (ICHD II) were interviewed by a headache specialist. Of 49 women with a history of MM currently using hormonal contraception, 23 reported amenorrhoea. Significantly more women with amenorrhoea reported no MO- days during the preceding month compared to women without amenorrhoea (OR 16.1; 95% confidence interval (CI) 1.8-140.4; P = 0.003). A reduction of MO-frequency was more often reported in women with than without amenorrhoea (OR 3.5; 95% CI 1.1-11.4; P = 0.04).ConclusionAmenorrhoea leads to a reduction of MO-frequency in women with MM using hormonal contraceptives. Future prospective studies on MM should focus on contraceptive methods that achieve amenorrhoea.

【 授权许可】

CC BY   
© Vetvik et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.