Migraine without aura is not associated with incomplete circle of Willis: a case–control study using high-resolution magnetic resonance angiography

The Journal of Headache and Pain

Short Report

Nanna Arngrim¹  Faisal Mohammad Amin¹  Anders Hougaard¹  Messoud Ashina¹  Shabnam Ezzatian-Ahar¹  Hayder Ghani Obaid²  Henrik B W Larsson² 

[1] Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, DK-2600, Glostrup, Denmark;Diagnostic Department, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, DK-2600, Glostrup, Denmark;

关键词: Circle of Willis;    Migraine without aura;    Cerebral arteries;    Stroke;   

DOI  :  10.1186/1129-2377-15-27

 received in 2014-03-23, accepted in 2014-05-05,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundThe circle of Willis is an important source of collateral blood flow to maintain adequate cerebral perfusion, particularly in the posterior circulation. Some studies report a relationship between incomplete circle of Willis and migraine, whereas other studies show no difference between the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.Using 3-Tesla magnetic resonance angiography we recorded three-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.FindingsWe found no difference between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252. Post hoc analysis showed a significant relationship between age and prevalence of incomplete circle of Willis, p = 0.003.ConclusionWe found no relationship between migraine without aura and incomplete circle of Willis.

【 授权许可】

Unknown   
© Ezzatian-Ahar et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.