The impact of depression and ghrelin on body weight in migraineurs

The Journal of Headache and Pain

Research Article

Dildar Konukoglu¹  Bulent Turan²  Zeynep Osar Siva³  Sabahattin Saip⁴  Baki Goksan⁴  Derya Uluduz⁴  Aksel Siva⁴  Feyza Erenler⁵ 

[1] Biochemistry Department, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey;Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA;Internal Medicine Department, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey;Neurology Department, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey;Undergraduate Medical Student, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Turkey;

关键词: Body weight;    Ghrelin;    Migraine;    Psychiatric comorbidity;    Depression;    Anxiety;   

DOI  :  10.1186/1129-2377-15-23

 received in 2014-03-19, accepted in 2014-04-14,  发布年份 2014

来源: Springer

【 摘 要 】

BackgroundComorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs.MethodsParticipants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers. Body mass index (BMI) was calculated by measuring height and weight. Ghrelin was assessed at fasting. Depression was assessed with the Hamilton Depression scale, and anxiety with the Hamilton Anxiety scale.ResultsThe data did not support the mediating role of ghrelin in the relationship between depression (or anxiety) and BMI for either the migraine or the control group. The interaction between ghrelin and depression as well as anxiety was significant for the migraine group, but not for the control group. Depressed (or anxious) migraineurs had a positive association between ghrelin and BMI, whereas for the non-depressed (or non-anxious) migraineurs this association was negative.ConclusionsDepression and anxiety moderated the effect of ghrelin on BMI for migraineurs. Management of anxiety and depression might be regarded as part of migraine treatment.

【 授权许可】

Unknown   
© Turan et al.; licensee Springer. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.