Transcriptome analyses reveal new insights on key determinants of perineural invasion in high-grade serous ovarian cancer

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Guoqiang Chen¹  Zhen Zheng²  Xiaolu Zhu²  Jing Chen²  Yincheng Teng²  Xiao Li² 

[1] Department of Obstetrics and Gynecology, Changzheng Hospital, Naval Medical University, Shanghai, China;Department of Obstetrics and Gynecology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China;

关键词: ovarian cancer;    neural invasion;    TAS2R receptor family proteins;    tumor immune microenvironment;    transcriptome;   

DOI  :  10.3389/fcell.2023.1109710

 received in 2022-11-28, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Perineural invasion (PNI) is a pathological feature of many cancers associated with poor outcomes, metastases, and recurrence. In relation to ovarian cancer (OC), there is no information about PNI’s role and mechanisms. Our study found that patients with PNI-positive symptoms had significantly shorter overall survival (OS) time than patients with PNI-negative symptoms. Multivariate analyses demonstrated that PNI represented a substantial independent prognostic factor in OC patients. At the transcriptome level, it is noteworthy that PNI positivity was negatively correlated with the degree of infiltration of immune killer cells in OC tumor tissues, including macrophage, central memory CD4 T-cell, natural killer cells, monocyte, and central memory CD4 T-cell. The results of this study revealed that TAS2Rs proteins were markedly upregulated in PNI-positive OC tissues and predicted poor prognoses. Moreover, Immunohistochemical analysis demonstrated that the TAS2R10 protein was associated with poor prognoses and PNI in OC. Consequently, we found for the first time that PNI was a powerful predictor of poor prognosis in OC and analyzed its expression pattern and some preliminary biochemical characterization, providing new clues for guiding clinical prevention and treatment of OC.

【 授权许可】

Unknown   
Copyright © 2023 Zheng, Li, Chen, Chen, Zhu and Teng.