Mastication stimuli regulate the heartbeat rate through rhythmic regulation by the hypothalamic-autonomic system; molecular and telemetric studies in weaning-stage rats

Frontiers in Neuroscience

Neuroscience

Tomiko Asakura¹  Seonmi Lee¹  Akihito Yasuoka²  Keiko Abe³  Yoshikazu Saito⁴  Toshitada Nagai⁵  Masayoshi Kuwahara⁶  Ryota Tochinai⁶ 

[1] Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Department of Human Nutrition, Seitoku University, Chiba, Japan;Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Project on Health and Anti-Aging, Kanagawa Academy of Science and Technology, Life Science and Environment Research Center (LiSE), Kawasaki, Japan;Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Toyo Institute of Food Technology, Hyogo, Japan;Department of Applied Biological Science, Faculty of Agriculture, Takasaki University of Health and Welfare, Gunma, Japan;Department of Veterinary Pathophysiology and Animal Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;

关键词: mastication;    weaning;    hypothalamus;    transcriptome;    heartbeat rate;    autonomic nerve;   

DOI  :  10.3389/fnins.2023.1260655

 received in 2023-07-19, accepted in 2023-09-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

Mastication stimuli have been demonstrated to affect memory function and autonomic nerve activity; however, this process has not been well studied during weaning compared to old age. Previously, we conducted molecular analyses of the thalamus and hippocampus to elucidate the mechanisms underlying this memory-enhancing effect in weaning-stage rats. In this study, we aimed to evaluate the effect of masticatory stimuli on the regulation of heartbeat rate (HR) through the hypothalamic-autonomic system. Three-week-old male rats were administered a powdered diet (P group) or chow-diet (C group) for 10 days. Thereafter, transcriptome analysis was performed. Vasopressin, cocaine-amphetamine-regulated transcript prepropeptide, corticotropin-releasing hormone, and thyrotropin-releasing hormone, which are involved in sympathetic activation of heart rate, were downregulated in the C group. Electrocardiograms were recorded continuously for 12 days under the same condition. Interestingly, rats in the C group had a significantly lower HR than those in the P group on day 11. We checked several parameters representing the autonomic regulation of HR. The C group had higher values for the high-frequency band integration of the HR power spectrum (parasympathetic marker) and root mean square successive difference of R-wave intervals (parasympathetic marker) relative to the P group. Such findings provide a molecular and physiological basis for understanding the regulation of cardiovascular function in response to masticatory stimuli in the autonomic nervous system.

【 授权许可】

Unknown   
Copyright © 2023 Lee, Tochinai, Yasuoka, Nagai, Saito, Kuwahara, Abe and Asakura.