Herpetic anterior uveitis following COVID-19 vaccines: a case series

Frontiers in Medicine

Medicine

Vishali Gupta¹  Francesco Pichi²  Aniruddha Agarwal³  Emmett T. Cunningham⁴  Dilraj S. Grewal⁵  Thanoosha Nagamany⁶  Souska Zandi⁶  Muriel Ott⁶  Marion R. Munk⁷  Ester Carreño⁸ 

[1] Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India;Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, United States;Cleveland Clinic Abu Dhabi, Eye Institute, Abu Dhabi, United Arab Emirates;Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, United States;Cleveland Clinic Abu Dhabi, Eye Institute, Abu Dhabi, United Arab Emirates;Department of Ophthalmology, Maastricht University Medical Center, Maastricht, Netherlands;Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, United States;Department of Ophthalmology, School of Medicine, Stanford University, Palo Atlo, CA, United States;The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, CA, United States;Department of Ophthalmology, Duke University, Durham, NC, United States;Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland;Augenarzt-Praxisgemeinschaft Gutblick AG, Pfäffikon, Switzerland;Feinberg School of Medicine, Northwestern University, Chicago, IL, United States;Department of Ophthalmology, University Hospital Fundación Jimenez Diaz, Madrid, Spain;

关键词: herpetic eye disease;    herpes zoster ophthalmicus;    ocular herpes simplex;    COVID-19 vaccines;    mRNA vaccination;    uveitis;    keratitis;    SARS-CoV-2 vaccination;   

DOI  :  10.3389/fmed.2023.1242225

 received in 2023-06-18, accepted in 2023-08-31,  发布年份 2023

来源: Frontiers

【 摘 要 】

PurposeTo report a case series of herpetic uveitis following COVID-19 vaccinations.MethodsDemographic, clinical and treatment-related data of herpetic anterior uveitis cases was collected at five tertiary eye hospitals between January 2021 and June 2022. A retrospective database review at one of the centers comparing the number of cases of herpetic eye disease before and after the introduction of COVID-19 vaccination was performed as well.ResultsTwenty-four patients (9 female, 15 male) with a mean age of 54 years (range 28–83 years) were diagnosed with herpetic uveitis, reporting an onset of symptoms 3–42 days after the first, second or third dose of COVID-19 vaccination. Median time between vaccination and onset of herpetic eye disease was 10 days (mean 12.7 ± 10.15 days) days. The administered vaccines were BNT162b2, mRNA-1273, BBIBP-CorV and Ad26.COV2.S. The cases included 11 HSV, 10 VZV and 1 CMV anterior uveitis, 2 were not further specified. There was an equal number of first episodes (n = 12, 50%) and recurrent episodes (n = 12, 50%). Response to established regimens was generally good. The retrospective database review revealed the exact same incidence of herpetic uveitis during the pandemic and ongoing vaccination compared to prior SARS-CoV-2.ConclusionThis report includes 24 cases of herpetic anterior uveitis in a temporal relationship to various COVID-19 vaccines. This study supports the potential risk of herpetic eye disease following COVID-19 vaccines, but proof of a direct, causal relationship is missing.

【 授权许可】

Unknown   
Copyright © 2023 Ott, Nagamany, Zandi, Pichi, Agarwal, Carreño, Gupta, Grewal, Cunningham and Munk.