Epidemiological and clinical characteristics of COVID-19 reinfection during the epidemic period in Yangzhou city, Jiangsu province

Frontiers in Public Health

Public Health

Lishun Xiao¹  Liguo Zhu²  Jianli Hu²  Jie Liang³  Jun Zhang³  Yuying Dong³  Yin Wang³  Yao Huang³  Cheng Wu³  Xin Zhou³  Huimin Yang³ 

[1] Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China;Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China;Yangzhou Center for Disease Control and Prevention, Yangzhou, Jiangsu, China;

关键词: SARS-CoV-2;    reinfection;    epidemiological characteristics;    clinical characteristics;    epidemic;   

DOI  :  10.3389/fpubh.2023.1256768

 received in 2023-07-11, accepted in 2023-08-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundWith the continuous progress of the epidemic of coronavirus disease 2019 (COVID-19) infection and the constant mutation of the virus strain, reinfection occurred in previously infected individuals and caused waves of the epidemic in many countries. Therefore, we aimed to explore the characteristics of COVID-19 reinfection during the epidemic period in Yangzhou and provide a scientific basis for assessing the COVID-19 situation and optimizing the allocation of medical resources.MethodsWe chose previously infected individuals of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reported locally in Yangzhou city from January 2020 to November 30, 2022. A telephone follow-up of cases was conducted from February to March 2023 to collect the COVID-19 reinfection information. We conducted a face-to-face survey on that who met the definition of reinfection to collect information on clinical symptoms, vaccination status of COVID-19, and so on. Data were analyzed using SPSS 19.0.ResultsAmong the 999 eligible respondents (92.24% of all the participants), consisting of 42.28% males and 57.72% females, the reinfection incidence of females was significantly higher than that of male cases (χ2 = 5.197, P < 0.05); the ages of the respondents ranged from 1 to 91 years, with the mean age of 42.28 (standard deviation 22.73) years; the most of the sufferers were infected initially with Delta variant (56.88%), followed by the Omicron subvariants BA.1/BA.2 (39.52%). Among all the eligible respondents, 126 (12.61%) reported COVID-19 reinfection appearing during the epidemic period, and the intervals between infections were from 73 to 1,082 days. The earlier the initial infection occurred, the higher the reinfection incidence and the reinfection incidence was significantly increased when the interval was beyond 1 year (P < 0.01) .119 reinfection cases (94.4%) were symptomatic when the most common symptoms included fever (65.54%) and cough (61.34%); compared with the initial infection cases, the proportion of clinical symptoms in the reinfected cases was significantly higher (P < 0.01). The reinfection incidence of COVID-19 vaccination groups with different doses was statistically significant (P < 0.01). Fewer reinfections were observed among the respondents with three doses of COVID-19 vaccination compared to the respondents with two doses (χ2 = 14.595, P < 0.001) or without COVID-19 vaccination (χ2 =4.263, P = 0.039).ConclusionAfter the epidemic period of COVID-19, the reinfection incidence varied with different types of SARS-CoV-2 strains. The reinfection incidence was influenced by various factors such as virus characteristics, vaccination, epidemic prevention policies, and individual variations. As the SARS-CoV-2 continues to mutate, vaccination and appropriate personal protection have practical significance in reducing the risk of reinfection.

【 授权许可】

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Copyright © 2023 Wang, Liang, Yang, Zhu, Hu, Xiao, Huang, Dong, Wu, Zhang and Zhou.