Case report: Blotchy skin in a puffy neonate: is there a new association?

Frontiers in Pediatrics

Pediatrics

Doan Le¹  Nicola A. M. Wright¹  Cora Constantinescu²  Arijit Lodha³  Majeeda Kamaluddeen⁴  Chacko J. Joseph⁴  Soumya R. Thomas⁴  Essa Al Awad⁴ 

[1] Alberta Health Services, Calgary, AB, Canada;Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Alberta Health Services, Calgary, AB, Canada;Section of Infectious Diseases, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada;Section of Neonatology, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Alberta Health Services, Calgary, AB, Canada;

关键词: purpura fulminans;    chylothorax;    congenital;    newborn;    pleural effusion;   

DOI  :  10.3389/fped.2023.1247343

 received in 2023-06-25, accepted in 2023-09-05,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionPurpura fulminans in the neonatal population is a rare but potentially life-threatening condition complicated by thrombosis, resultant vital organ necrosis, and gangrene of the extremities. Considering the rapid evolution of the pathogenetic mechanism, an index of suspicion, early identification, and prompt intervention are imperative for improved outcomes. The majority of purpura fulminans cases have an infectious etiology, but it is essential to consider other congenital and acquired causes.Case descriptionWe present a clinical case of a female neonate to emphasize the correlation between purpura fulminans, congenital chylothorax, involvement of the PAK2 gene, and the occurrence of retinal detachment in both eyes. After draining the congenital chylothorax, the neonate developed purpura fulminans due to a loss of protein C, S, and antithrombin factors, previously not reported in the literature. The purpuric lesions resolved after the administration of fresh frozen plasma. Subsequently, no recurring purpura fulminans lesions were noted following the normalization of the antithrombotic factor levels in the serum. Subsequently, the child also developed retinal detachment in both eyes.

【 授权许可】

Unknown   
© 2023 Joseph, Lodha, Thomas, Al Awad, Wright, Constantinescu, Le and Kamaluddeen.