Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines

Frontiers in Chemistry

Chemistry

Yusuke Sasano¹  Yuse Kuriyama¹  Yoshiharu Iwabuchi² 

[1] Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan;null;

关键词: azetidine;    epoxide;    catalytic reaction;    regioselectivity;    cyclization;    Lewis acid;    synthetic methods;   

DOI  :  10.3389/fchem.2023.1251299

 received in 2023-07-01, accepted in 2023-08-22,  发布年份 2023

来源: Frontiers

【 摘 要 】

Azetidine is a prevalent structural motif found in various biologically active compounds. In this research paper, we report La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines to afford azetidines. This reaction proceeded in high yields even in the presence of acid-sensitive and Lewis basic functional groups.

【 授权许可】

Unknown   
Copyright © 2023 Kuriyama, Sasano and Iwabuchi.

【 图 表 】

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