Effects of clinical medications on male fertility and prospects for stem cell therapy

Frontiers in Cell and Developmental Biology

Cell and Developmental Biology

Xinpeng Ke¹  Ziran Zhao¹  Peiting Mo¹  Yong Fan²  Chaohui Li³ 

[1] Key Laboratory for Major Obstetric Diseases of Guangdong Province, Department of Obstetrics and Gynecology, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China;[e-mail];null;

关键词: male fertility;    clinical medications;    spermatogenesis;    stem cell therapy;    exosomes therapy;   

DOI  :  10.3389/fcell.2023.1258574

 received in 2023-07-14, accepted in 2023-09-07,  发布年份 2023

来源: Frontiers

【 摘 要 】

An increasing number of men require long-term drug therapy for various diseases. However, the effects of long-term drug therapy on male fertility are often not well evaluated in clinical practice. Meanwhile, the development of stem cell therapy and exosomes treatment methods may provide a new sight on treating male infertility. This article reviews the influence and mechanism of small molecule medications on male fertility, as well as progress of stem cell and exosomes therapy for male infertility with the purpose on providing suggestions (recommendations) for evaluating the effect of drugs on male fertility (both positive and negative effect on male fertility) in clinical application and providing strategies for diagnosis and treatment of male infertility.

【 授权许可】

Unknown   
Copyright © 2023 Mo, Zhao, Ke, Fan and Li.