Impact of an online guided physical activity training on cognition and gut-brain axis interactions in older adults: protocol of a randomized controlled trial

Frontiers in Aging Neuroscience

Aging Neuroscience

André Scherag¹  Christiane Frahm²  Simon J. Schrenk²  Monique Radscheidt²  Adriana L. Ruiz-Rizzo²  Otto W. Witte²  Tannaz Saraei²  Stefan Brodoehl²  Fabian Kattlun³  Kathrin Finke³  Christian Gaser⁴  Hans-Josef Müller⁵  Rami Abou Hamdan⁵  Thomas Steidten⁵  Christian Puta⁶  Marco Herbsleb⁷  Christoph Kaleta⁸  Stefano Flor⁸ 

[1] Center for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Center for Clinical Studies, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Department of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Department of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Center for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Department of Neurology, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Department of Psychiatry and Psychotherapy, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, Germany;Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, Germany;Center for Sepsis Control and Care (CSCC), Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Center for Interdisciplinary Prevention of Diseases Related to Professional Activities, Friedrich-Schiller-University Jena, Jena, Germany;Department of Sports Medicine and Health Promotion, Friedrich-Schiller-University Jena, Jena, Germany;Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital – Friedrich Schiller University of Jena, Jena, Germany;Institute of Experimental Medicine, Christian-Albrechts-University zu Kiel, Kiel, Germany;

关键词: cognition;    physical activity;    online intervention;    fMRI;    healthy;    older adults;    microbiome;   

DOI  :  10.3389/fnagi.2023.1254194

 received in 2023-07-06, accepted in 2023-08-30,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionBy 2050, the worldwide percentage of people 65 years and older is assumed to have doubled compared to current numbers. Therefore, finding ways of promoting healthy (cognitive) aging is crucial. Physical activity is considered an effective approach to counteract not only physical but also cognitive decline. However, the underlying mechanisms that drive the benefits of regular physical activity on cognitive function are not fully understood. This randomized controlled trial aims to analyze the effect of an eight-week standardized physical activity training program in older humans on cognitive, brain, and gut-barrier function as well as the relationship between the resulting changes.Methods and analysisOne-hundred healthy participants aged 60 to 75 years will be recruited. First, participants will undergo an extensive baseline assessment consisting of neurocognitive tests, functional and structural brain imaging, physical fitness tests, and gut-microbiome profiling. Next, participants will be randomized into either a multi-component physical activity group (experimental condition) or a relaxation group (active control condition), with each training lasting 8 weeks and including an equal number and duration of exercises. The whole intervention will be online-based, i.e., participants will find their intervention schedule and all materials needed on the study website. After the intervention phase, participants will have their post-intervention assessment, which consists of the same measures and tests as the baseline assessment. The primary outcome of this study is the change in the cognitive parameter of visual processing speed from baseline to post-measurement, which will on average take place 10 weeks after the randomization. Secondary outcomes related to cognitive, brain, and microbiome data will be analyzed exploratory.Clinical trial registration:https://drks.de/search/de/trial/DRKS00028022

【 授权许可】

Unknown   
Copyright © 2023 Schrenk, Brodoehl, Flor, Frahm, Gaser, Hamdan, Herbsleb, Kaleta, Kattlun, Müller, Puta, Radscheidt, Ruiz-Rizzo, Saraei, Scherag, Steidten, Witte and Finke.