Local excision and radical excision for rectal gastrointestinal stromal tumors: a meta-analysis protocol

Frontiers in Oncology

Oncology

Zhou Zhao¹  Wenjun Luo²  Haidong Zhang²  Chaoyong Shen²  Bo Zhang²  Tianxiang Jiang²  Zhaolun Cai²  Xiaonan Yin²  Mingchun Mu²  Chunyu Liu³  Luyin Han⁴ 

[1] Department of Gastrointestinal Cancer Center, Chongqing University Cancer Hospital, Chongqing, China;Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China;Gastric Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China;Department of Pharmacy, Evidence-based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China;Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan, China;

关键词: gastrointestinal stromal tumors;    GIST;    rectal;    local excision;    radical excision;   

DOI  :  10.3389/fonc.2023.1224725

 received in 2023-05-18, accepted in 2023-08-24,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundTo date, several studies have compared the surgical and oncological outcomes of local excision (LE) and radical excision (RE) for rectal gastrointestinal stromal tumors (GISTs), but some have limited numbers of small series. This protocol outlines the planned scope and methods for a systematic review and meta-analysis that will compare the surgical and oncological outcomes of LE and RE in patients with rectal GISTs.MethodsThis protocol is presented in accordance with the PRISMA-P guideline. PubMed, Embase, Web of Science, Cochrane Library and Wanfang database will be systematically searched. Furthermore, reference lists of all included articles will be screened manually to add other eligible studies. We will include randomized controlled trials (RCTs) and non-randomized studies (NRS) in this study. The primary outcomes evaluated will be R0 resection rate and disease-free survival, while the secondary outcomes will contain overall survival, length of stay, tumor rupture rate and complications. Two reviewers will independently screen and select studies, extract data from the included studies, and assess the risk of bias of the included studies. Preplanned subgroup analyses and sensitivity analyses are detailed within this protocol. The strength of the body of evidence will be assessed using GRADEDiscussionThis review and meta-analysis will provide a comprehensive evaluation of the current evidence concerning the application of LE and RE in patients with rectal GISTs. The findings from this review will serve as a foundation for future research and emphasize the implications for clinical practice.Systematic review registrationPROSPERO (CRD42017078338), https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=387409, PROSPERO CRD42017078338.

【 授权许可】

Unknown   
Copyright © 2023 Luo, Liu, Han, Zhang, Shen, Yin, Zhao, Mu, Jiang, Cai and Zhang