The roles of FGF21 and GDF15 in mediating the mitochondrial integrated stress response

Frontiers in Endocrinology

Endocrinology

Renata O. Pereira¹  Luis Miguel García-Peña¹  Jayashree Jena¹ 

[1] Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, United States;

关键词: mitochondrial stress;    FGF21;    GDF15;    integrated stress response;    metabolic health;    energy balance;   

DOI  :  10.3389/fendo.2023.1264530

 received in 2023-07-20, accepted in 2023-09-11,  发布年份 2023

来源: Frontiers

【 摘 要 】

Various models of mitochondrial stress result in induction of the stress-responsive cytokines fibroblast growth factor 21 (FGF21) and growth differentiation factor 15 (GDF15). This is an adaptive mechanism downstream of the mitochondrial integrated stress response frequently associated with improvements in systemic metabolic health. Both FGF21 and GDF15 have been shown to modulate energy balance and glucose homeostasis, and their pharmacological administration leads to promising beneficial effects against obesity and associated metabolic diseases in pre-clinical models. Furthermore, endogenous upregulation of FGF21 and GDF15 is associated with resistance to diet-induced obesity (DIO), improved glucose homeostasis and increased insulin sensitivity. In this review, we highlight several studies on transgenic mouse models of mitochondrial stress and will compare the specific roles played by FGF21 and GDF15 on the systemic metabolic adaptations reported in these models.

【 授权许可】

Unknown   
Copyright © 2023 Jena, García-Peña and Pereira